Analytical Data
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基因名
NAPRT
- Application
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别名
NAPRT；FHIP；NAPRT1；Nicotinate phosphoribosyltransferase
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q6XQN6
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表达区间
229-538aa
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氨基酸序列
MLAPAAGEGPGVDLAAKAQVWLEQVCAHLGLGVQEPHPGERAAFVAYALAFPRAFQGLLDTYSVWRSGLPNFLAVALALGELGYRAVGVRLDSGDLLQQAQEIRKVFRAAAAQFQVPWLESVLIVVSNNIDEEALARLAQEGSEVNVIGIGTSVVTCPQQPSLGGVYKLVAVGGQPRMKLTEDPEKQTLPGSKAAFRLLGSDGSPLMDMLQLAEEPVPQAGQELRVWPPGAQEPCTVRPAQVEPLLRLCLQQGQLCEPLPSLAESRALAQLSLSRLSPEHRRLRSPAQYQVVLSERLQALVNSLCAGQSP
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分子量
35.2 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NAPRT (Nicotinate Adenine Dinucleotide Phosphate Regenerator) is a key enzyme involved in the NAD+ biosynthetic pathway, specifically catalyzing the conversion of nicotinate to NAD+, an essential cofactor in various metabolic processes. Research into NAPRT and its recombinant proteins has gained momentum due to its significance in cellular metabolism and energy production, making it a potential target for therapeutic applications. Disruption of NAD+ levels has been implicated in various diseases, including metabolic disorders, neurodegenerative diseases, and cancer. Therefore, understanding the structure, function, and regulatory mechanisms of NAPRT can provide valuable insights into its role in these conditions. Additionally, recombinant NAPRT proteins can serve as valuable tools for studying NAD+ metabolism and developing novel strategies for drug discovery. The exploration of NAPRT’s enzymatic properties and its interactions with other cellular components can pave the way for innovative approaches to modulate NAD+ levels in diseased states, thus highlighting the importance of NAPRT in both basic research and potential clinical applications.
