Analytical Data
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基因名
KNG1
- Application
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别名
KNG1；BDK；KNG；Kininogen-1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P01042-2
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表达区间
19-380aa
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氨基酸序列
MASMTGGQQMGRGHHHHHHGNLYFQGGEFQESQSEEIDCNDKDLFKAVDA ALKKYNSQNQSNNQFVLYRITEATKTVGSDTFYSFKYEIKEGDCPVQSGK TWQDCEYKDAAKAATGECTATVGKRSSTKFSVATQTCQITPAEGPVVTAQ YDCLGCVHPISTQSPDLEPILRHGIQYFNNNTQHSSLFMLNEVKRAQRQV VAGLNFRMTYSIVQTNCSKENFLFLTPDCKSLWNGDTGECTDNAYIDIQL RIASFSQNCDIYPGKDFVQPPTKICVGCPRDIPTNSPELEETLTHTITKL NAENNATFYFKIDNVKKARVQVVAGKKYFIDFVARETTCSKESNEELTES CETKKLGQSLDCNAEVYVVPWEKKIYPTVNCQPLGMISLMK
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分子量
48 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KNG1, or Kininogen 1, is a multifaceted protein that plays a crucial role in the kinin-generating system, which is involved in various physiological processes, including inflammation, blood pressure regulation, and pain sensitization. The study of KNG1 recombinant proteins has gained significant attention due to its potential implications in understanding cardiovascular diseases, chronic pain, and other inflammatory conditions. Research has shown that KNG1 can influence bradykinin release, thereby modulating vascular permeability and contributing to the pathophysiology of various diseases. Additionally, mutations or variations in the KNG1 gene have been linked to altered susceptibility to certain diseases, making it a notable target for therapeutic intervention. The recombinant production of KNG1 allows for detailed functional studies, providing insights into its structure-function relationships and facilitating the development of KNG1-based drugs or biomaterials. Understanding the molecular mechanisms underlying KNG1's role in health and disease can pave the way for novel therapeutic strategies and enhance our comprehension of the complex biological pathways that govern inflammation and vascular health. Consequently, ongoing research into KNG1 recombinant proteins is crucial for elucidating their potential roles in clinical applications and advancing medical science.
