Analytical Data
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Gene name
GADD45B
- Application
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Alternative Names
GADD45B；MYD118；Growth arrest and DNA damage-inducible Protein GADD45 beta
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O75293
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Expression Region
1-160aa
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AA Sequence
MTLEELVACD NAAQKMQTVT AAVEELLVAA QRQDRLTVGV YESAKLMNVD PDSVVLCLLA IDEEEEDDIA LQIHFTLIQS FCCDNDINIV RVSGMQRLAQ LLGEPAETQG TTEARDLHCL LVTNPHTDAW KSHGLVEVAS YCEESRGNNQ WVPYISLQER
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The GADD45B (Growth Arrest and DNA Damage-inducible protein 45 beta) is part of the GADD45 family, which plays a crucial role in cellular stress responses, DNA repair, and apoptosis. Its involvement in various physiological processes, including cell cycle regulation and immune responses, has drawn considerable research interest. Studies have shown that GADD45B is upregulated in response to genotoxic stress and is implicated in tumorigenesis, making it a potential biomarker and therapeutic target in cancer research. The recombinant protein of GADD45B has been produced to study its structure-function relationships and interactions with other cellular proteins. Investigating the biochemical properties and signaling pathways associated with GADD45B can shed light on its role in maintaining genomic stability and its potential implications in cancer therapy. Understanding these mechanisms may offer insights into designing novel therapeutic strategies that leverage GADD45B's functions in tumor suppression and cell survival in the face of DNA damage.
