Analytical Data
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基因名
CNTNAP2
- Application
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别名
CNTNAP2；CASPR2；KIAA0868；Contactin-associated Protein-like 2
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种属
Mouse
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9CPW0
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表达区间
1-1262aa
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氨基酸序列
MVMSLRAGYR AALSLWILSS FICRAWTAPS TFQKCDEPLI SGLPHVSFSS SSSLSSSYAP GYAKINKRGG AGGWSPSDSD HYQWLQVDFG NRKQISAIAT QGRYSSSDWV TQYRMLYSDT GRNWKPYHQD GNIWAFPGNI NSDSVVRHDL QHAVVARYVR IVPLDWNGEG HIGLRAEVYG CAYWADVINF DGHGVLPYRF RNKKMKTLKD VIALKFKTSE SEGVLLHGEG QQGDYITLEL KKAKLVLSLN LGSNQLGPIY GHTSVTSGSL LDDHHWHSVL IERQGRSINL TLDRSMQHFR TNGEFDYLDL DYEITFGGIP FSGKPSSSNR KNFKGCMESI NYNGVNITDL ARRKKLGPSN MGNLSFSCVE PYTVPVFFNA TSYLEVPGRL NQDLFSVSFQ FRTWNPSGLL LFSHFADNLG NVEIDLVESK VGVHINNTQT KTSQIDISSG SGLNDGQWHE VRFLAKENFA VLTIDGDEAS AVRTNSPLQV KTGEKYFFGG FLNHMNNASY SALQPSFQGC MQLIQVDDQL VNLYEVAQRK PGSFANVTID MCAIIDRCVP NHCEHGGKCS QTWDSFKCTC DETGYSGATC HNSIYEPSCE AYKHLGQTSN YYWIDPDGSG PLGPLKVYCN MTEDKVWTIV SHDLQMQTTV VGYNPEKYSV TQLIYSASMD QISAITSSAE YCEQYVSYFC RMSRLLNTPD GSPYTWWVGK ANEKHYYWGG SEPGIQKCAC GIERNCTDPK YYCNCDADYK QWRKDAGFLS YKDHLPVSQV VVGDTDRQGS EAKLSVGPLR CQGDRNYWNA ASFPNPSSYL HFSTFQGETS ADISFYFKTL IPRGVFLENL GNTDFIKLEL KSATEVSFSF DVGNGPVEIV VRSPSPLNDD QWHRVTAERN VKQASLQVDR LPQQIRKAPT EGHTRLELYS QLFVGGAGGQ QGFLGCIRSL RMNGVTLDLE ERAKVTSGFK SGCSGHCTSY GANCENGGKC IEKYHGYSCD CSNTAYDGTF CNKDVGAFFE EGMWLRYNFQ APAVTARDTG SRAENSADQQ QHLAPDLAQE QIHFSFSTTK APCILLYVSS LTTDFLAVLV KPTGNLQIRY NLGGTREPFN IDVDHRNMAN GQPHSVNITR HERTIILKLD HYPAVGYHLP SSSDTLFNSP KSLFLGKVIE TGKIDQEIHK YNTPGFTGCL SRVQFNHIAP LKAALRQTNA SAHVHIQGEL VESNCGASPL TLSPMSSATD PWHLDHLDSA SADFPYNPGQ GQAIRNGVNR NS
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分子量
139 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CNTNAP2 (Contactin-Associated Protein 2) is a gene located on chromosome 7 that encodes for a protein crucial in neuronal development and functioning, particularly in the formation of the axon-glia complex, which is essential for maintaining neuronal integrity and facilitating signal transmission. Variations and mutations in the CNTNAP2 gene have been linked to various neurodevelopmental disorders, including autism spectrum disorder (ASD), specific language impairment (SLI), and schizophrenia. Given its significant role in neural connectivity and synaptic functioning, CNTNAP2 has become a focal point in understanding the genetic underpinnings of these disorders. Research on recombinant CNTNAP2 protein aims to elucidate its structure, function, and interaction with other neuronal proteins, potentially revealing mechanisms of action that contribute to neurodevelopmental pathologies. By producing and studying this recombinant protein, scientists can investigate its role in cellular processes, such as adhesion, signaling, and axonal transport, and assess how disruptions in its function may lead to the manifestations of various neurodevelopmental conditions. Insights gained from these studies might inform therapeutic strategies targeting CNTNAP2-related pathways and assist in the development of interventions aimed at ameliorating cognitive and communicative deficits associated with neurodevelopmental disorders. Ultimately, understanding the multifaceted roles of CNTNAP2 through recombinant protein research holds promise for advancing our comprehension of neurodevelopmental health and disease.
