Analytical Data
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基因名
RBM15
- Application
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别名
One twenty two protein ; One-twenty two protein 1; OTT; OTT1; Putative RNA-binding protein 15; RBM15; RBM15_HUMAN; RNA binding motif protein 15; RNA-binding motif protein 15
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96T37
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表达区间
1-563 aa
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氨基酸序列
MPEDDQRATRNLFIGNLDHSVSEVELRRAFEKYGIIEEVVIKRPARGQGGAYAFLKFQNLDMAHRAKVAMSGRVIGRNPIKIGYGKANPTTRLWVGGLGPNTSLAALAREFDRFGSIRTIDHVKGDSFAYIQYESLDAAQAACAKMRGFPLGGPDRRLRVDFAKAEETRYPQQYQPSPLPVHYELLTDGYTRHRNLDADLVRDRTPPHLLYSDRDRTFLEGDWTSPSKSSDRRNSLEGYSRSVRSRSGERWGADGDRGLPKPWEERRKRRSLSSDRGRTTHSPYEERSRTKGSGQQSERGSDRTPERSRKENHSSEGTKESSSNSLSNSRHGAEERGHHHHHHEAADSSHGKKARDSERNHRTTEAEPKPLEEPKHETKKLKNLSEYAQTLQLGWNGLLVLKNSCFPTSMHILEGDQGVISSLLKDHTSGSKLTQLKIAQRLRLDQPKLDEVTRRIKQGSPNGYAVLLATQATPSGLGTEGMPTVEPGLQRRLLRNLVSYLKQKQAAGVISLPVGGSKGRDGTGMLYAFPPCDFSQQYLQSALRTLGKLEEEHMVIVIVRDTA
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分子量
88.33 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RBM15 (RNA-binding motif protein 15) is a key regulator in various biological processes, including RNA splicing, gene expression, and cell differentiation. Research into RBM15 has gained momentum due to its significant role in hematopoiesis and its association with specific hematological malignancies. The protein is part of the splicing factor complex and is implicated in the regulation of alternative splicing events, which can impact cell fate decisions. Recent studies have highlighted the importance of RBM15 in maintaining stem cell properties and its involvement in the development of acute myeloid leukemia (AML), where it may act as an oncogenic factor. The understanding of RBM15 function is further complicated by the presence of several isoforms and the interplay with other regulatory proteins. Furthermore, the study of RBM15's role in gene expression regulation and its potential as a therapeutic target underscores the need for detailed analysis of its domain structure and interaction networks. Consequently, the generation of recombinant RBM15 protein has become a focal point of research, enabling researchers to dissect its molecular functions and explore its potential roles in disease mechanisms and novel therapeutic strategies. By investigating the biochemical properties and interactions of RBM15, researchers aim to elucidate its contributions to normal cellular processes and how its dysregulation may lead to pathologies, thereby opening new avenues for targeted therapies in cancers and other diseases where RBM15 plays a crucial role.
