Analytical Data
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基因名
US11
- Application
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别名
US11；Small ribosomal subunit Protein uS11
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种属
E.coli
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P0A7R9
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表达区间
2-129aa
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氨基酸序列
AKAPIRARKRVRKQVSDGVAHIHASFNNTIVTITDRQGNALGWATAGGSGFRGSRKSTPFAAQVAAERCADAVKEYGIKNLEVMVKGPGPGRESTIRALNAAGFRITNITDVTPIPHNGCRPPKKRRV
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分子量
17.7 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
US11 is a type of protein encoded by the human cytomegalovirus (HCMV), which belongs to the herpesvirus family. It plays a crucial role in the virus's ability to evade the host immune response, thereby enhancing viral persistence and pathogenesis. Research has shown that US11 is involved in the modulation of Major Histocompatibility Complex (MHC) class I expression on the surface of infected cells, which is essential for the recognition and elimination of infected cells by CD8+ T cells. By downregulating MHC class I molecules, US11 helps HCMV escape immune surveillance, posing significant challenges for vaccine development and therapeutic strategies. The study of US11 and its mechanisms of action is vital for understanding HCMV biology and pathogenesis, as well as for developing potential antiviral therapies. Recent advances in molecular biology and structural analysis techniques have allowed for deeper insights into the function of US11, opening avenues for targeted interventions that could enhance the effectiveness of immune responses against HCMV. Given its critical role in immune evasion, US11 represents a promising target for therapeutic development aimed at controlling HCMV-related diseases, particularly in immunocompromised individuals, where the virus can cause severe complications. Consequently, ongoing research into the structural, functional, and immunological aspects of US11 is essential for elucidating its role in HCMV infection and for the potential design of effective antiviral strategies.
