Analytical Data
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Gene name
RRAGD
- Application
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Alternative Names
bA11D8.2.1; DKFZp761H171; FLJ44176; OTTHUMP00000016853; Rag D; Rag D protein; RagD; RagDRRAGD; Ras related GTP binding D; Ras-related GTP binding protein D; Ras-related GTP-binding protein D; RRAGD; RRAGD_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NQL2
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Expression Region
1-400 aa
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AA Sequence
MSQVLGKPQP QDEDDAEEEE EEDELVGLAD YGDGPDSSDA DPDSGTEEGV LDFSDPFSTE VKPRILLMGL RRSGKSSIQK VVFHKMSPNE TLFLESTNKI CREDVSNSSF VNFQIWDFPG QIDFFDPTFD YEMIFRGTGA LIFVIDSQDD YMEALARLHL TVTRAYKVNT DINFEVFIHK VDGLSDDHKI ETQRDIHQRA NDDLADAGLE KIHLSFYLTS IYDHSIFEAF SKVVQKLIPQ LPTLENLLNI FISNSGIEKA FLFDVVSKIY IATDSTPVDM QTYELCCDMI DVVIDISCIY GLKEDGAGTP YDKESTAIIK LNNTTVLYLK EVTKFLALVC FVREESFERK GLIDYNFHCF RKAIHEVFEV RMKVVKSRKV QNRLQKKKRA TPNGTPRVLL
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Molecular Weight
45.5 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RRAGD is a member of the RAG (Ras-like GTPase) family, which plays a crucial role in cellular signaling pathways, particularly in the regulation of mTOR (mammalian target of rapamycin) signaling. This protein is known to function as a molecular switch that toggles between active and inactive states in response to cellular nutrient availability and growth signals. The study of RRAGD has gained significant interest due to its implications in cancer biology, where dysregulation of mTOR signaling is often implicated in tumor growth and progression. Researchers have been increasingly focused on understanding the precise mechanisms by which RRAGD interacts with other signaling molecules to influence cellular metabolism and growth. Additionally, its potential as a therapeutic target for metabolic disorders and cancer treatment is being explored, as modulation of RRAGD activity could provide innovative strategies to restore normal signaling pathways in diseased cells. Investigating the structure and function of RRAGD, including its interactions with GTP and other cellular partners, will further elucidate its role in health and disease, paving the way for novel approaches in targeted therapies.
