Analytical Data
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Gene name
RSAD2
- Application
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Alternative Names
2510004L01Rik; cig 33; CIG 5; cig-33; CIG-5; CIG33; CIG5; Cytomegalovirus induced gene 5 protein ; Cytomegalovirus-induced gene 5 protein; endoplasmic reticulum-associated; interferon-inducible; Radical S adenosyl methionine domain containing 2; Radical S-adenosyl methionine domain-containing protein 2; RSAD 2; Rsad2; RSAD2_HUMAN; RSDA-2; VIG 1; vig1; Viperin; Virus inhibitory protein; virus inhibitory protein endoplasmic reticulum associated interferon inducible
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8WXG1
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Expression Region
1-361 aa
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AA Sequence
MWVLTPAAFA GKLLSVFRQP LSSLWRSLVP LFCWLRATFW LLATKRRKQQ LVLRGPDETK EEEEDPPLPT TPTSVNYHFT RQCNYKCGFC FHTAKTSFVL PLEEAKRGLL LLKEAGMEKI NFSGGEPFLQ DRGEYLGKLV RFCKVELRLP SVSIVSNGSL IRERWFQNYG EYLDILAISC DSFDEEVNVL IGRGQGKKNH VENLQKLRRW CRDYRVAFKI NSVINRFNVE EDMTEQIKAL NPVRWKVFQC LLIEGENCGE DALREAERFV IGDEEFERFL ERHKEVSCLV PESNQKMKDS YLILDEYMRF LNCRKGRKDP SKSILDVGVE EAIKFSGFDE KMFLKRGGKY IWSKADLKLD W
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Molecular Weight
42.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RSAD2, also known as radical S-adenosyl methionine domain 2, is a protein that plays a critical role in the innate immune response, particularly during viral infections. It is recognized for its ability to interfere with viral replication and promote antiviral defense mechanisms. Upon viral infection, RSAD2 expression is upregulated, suggesting its involvement in the cellular response to pathogen invasion. Research indicates that RSAD2 possesses a unique antiviral activity by promoting the formation of specific cellular structures, including antiviral bodies and filaments, which can sequester viral components and inhibit their replication. Additionally, RSAD2 can modulate various signaling pathways linked to inflammation and immune response, further highlighting its importance in host defense. Studies have shown that RSAD2's mechanisms of action involve interactions with other proteins and cellular components that facilitate the restriction of viral spread and enhance the activity of immune cells. Given the increasing prevalence of viral infections and the need for effective therapeutic strategies, understanding the function, regulation, and potential applications of RSAD2 in antiviral therapies has become a significant focus in molecular and clinical research. Researchers are exploring the potential of RSAD2 as a target for drug development, as well as its utility as a biomarker for viral infections. The ongoing studies aim to elucidate the complex roles of RSAD2 in various pathogens, advancing our knowledge of immune responses and opening new avenues for innovative treatments in virology and infectious disease management.
