Analytical Data
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Gene name
SETD3
- Application
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Alternative Names
C14orf154; Chromosome 14 open reading frame 154 ; DKFZp761E1415; FLJ23027; Histone lysine N methyltransferase setd3; Histone-lysine N-methyltransferase setd3; MGC87236; SET domain containing 3; SET domain containing protein 3; SET domain-containing protein 3; SETD 3; Setd3; SETD3_HUMAN
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86TU7
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Expression Region
1-594 aa
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AA Sequence
MGKKSRVKTQ KSGTGATATV SPKEILNLTS ELLQKCSSPA PGPGKEWEEY VQIRTLVEKI RKKQKGLSVT FDGKREDYFP DLMKWASENG ASVEGFEMVN FKEEGFGLRA TRDIKAEELF LWVPRKLLMT VESAKNSVLG PLYSQDRILQ AMGNIALAFH LLCERASPNS FWQPYIQTLP SEYDTPLYFE EDEVRYLQST QAIHDVFSQY KNTARQYAYF YKVIQTHPHA NKLPLKDSFT YEDYRWAVSS VMTRQNQIPT EDGSRVTLAL IPLWDMCNHT NGLITTGYNL EDDRCECVAL QDFRAGEQIY IFYGTRSNAE FVIHSGFFFD NNSHDRVKIK LGVSKSDRLY AMKAEVLARA GIPTSSVFAL HFTEPPISAQ LLAFLRVFCM TEEELKEHLL GDSAIDRIFT LGNSEFPVSW DNEVKLWTFL EDRASLLLKT YKTTIEEDKS VLKNHDLSVR AKMAIKLRLG EKEILEKAVK SAAVNREYYR QQMEEKAPLP KYEESNLGLL ESSVGDSRLP LVLRNLEEEA GVQDALNIRE AISKAKATEN GLVNGENSIP NGTRSENESL NQESKRAVED AKGSSSDSTA GVKE
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Molecular Weight
67.2 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
SETD3 (SET domain containing 3) is a member of the SET domain family of proteins, which are known to function as histone methyltransferases, playing crucial roles in the regulation of gene expression, chromatin modification, and cellular processes. The research surrounding SETD3 has gained momentum due to its critical involvement in various biological processes, including cell differentiation and development, as well as its association with specific diseases such as cancer. Recent studies have indicated that SETD3 may play a pivotal role in the methylation of histones and non-histone proteins, influencing both transcriptional regulation and cellular signaling pathways. However, the exact mechanisms by which SETD3 exerts its effects at the molecular level remain largely unexplored. To investigate its biological functions and potential therapeutic applications, the recombinant protein of SETD3 is being studied extensively. By producing SETD3 as a recombinant protein, researchers aim to elucidate its structural and functional properties, understand its interactions with other cellular molecules, and define its role in pathophysiological contexts. Moreover, the exploration of SETD3’s enzymatic activity and the identification of its target substrates are crucial for unveiling its potential as a biomarker or a therapeutic target. Overall, the ongoing research on SETD3 recombinant protein holds promise for advancing our understanding of methylation processes and their implications in human health and disease.
