Analytical Data
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基因名
CSNK1A1L
- Application
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别名
CSNK1A1L；Casein kinase I isoform alpha-like
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8N752
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表达区间
1-337aa
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氨基酸序列
MTNNSGSKAELVVGGKYKLVRKIGSGSFGDVYLGITTTNGEEVAVKLESQ KVKHPQLLYESKLYTILQGGVGIPHMHWYGQEKDNNVLVMDLLGPSLEDL FNFCSRRFTMKTVLMLADQMISRIEYVHTKNFLHRDIKPDNFLMGTGRHC NKLFLIDFGLAKKYRDNRTRQHIPYREDKHLIGTVRYASINAHLGIEQSR RDDMESLGYVFMYFNRTSLPWQGLKAMTKKQKYEKISEKKMSTPVEVLCK GFPAEFAMYLNYCRGLRFEEVPDYMYLRQLFRILFRTLNHQYDYTFDWTM LKQKAAQQAASSSGQGQQAQTQTGKQTEKNKNNVKDN
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分子量
64 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CSNK1A1L, or Casein Kinase 1 Alpha 1-Like, is a member of the casein kinase 1 (CK1) family of serine/threonine kinases, which play critical roles in various cellular processes, including cell signaling, circadian rhythms, and cell cycle regulation. The study of CSNK1A1L is significant due to its involvement in key biological pathways and its potential implications in various diseases, particularly cancer and neurological disorders. The kinase activity of CSNK1A1L is essential for the phosphorylation of downstream substrates, influencing signaling cascades that mediate cellular responses to environmental stimuli. Recent research has highlighted its role in modulating pathways related to Wnt signaling, which is crucial for embryonic development and tissue homeostasis. Additionally, abnormal regulation of CSNK1A1L has been linked to pathological conditions, making it a promising target for therapeutic intervention. The generation of recombinant CSNK1A1L protein is vital for functional studies, enabling researchers to investigate its enzymatic properties, substrate specificity, and interaction with other proteins. This understanding could pave the way for the development of novel treatments that target CK1 family kinases, enhancing our ability to manipulate these pathways in disease contexts. Overall, ongoing research into CSNK1A1L aims to elucidate its biological significance and therapeutic potential, fostering advancements in cancer treatment and the management of neurodegenerative disorders.
