Analytical Data
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Gene name
DTX1
- Application
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Alternative Names
DTX1；E3 ubiquitin-Protein ligase DTX1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q86Y01
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Expression Region
1-620aa
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AA Sequence
MSRPGHGGLM PVNGLGFPPQ NVARVVVWEW LNEHSRWRPY TATVCHHIEN VLKEDARGSV VLGQVDAQLV PYIIDLQSMH QFRQDTGTMR PVRRNFYDPS SAPGKGIVWE WENDGGAWTA YDMDICITIQ NAYEKQHPWL DLSSLGFCYL IYFNSMSQMN RQTRRRRRLR RRLDLAYPLT VGSIPKSQSW PVGASSGQPC SCQQCLLVNS TRAASNAILA SQRRKAPPAP PLPPPPPPGG PPGALAVRPS ATFTGAALWA APAAGPAEPA PPPGAPPRSP GAPGGARTPG QNNLNRPGPQ RTTSVSARAS IPPGVPALPV KNLNGTGPVH PALAGMTGIL LCAAGLPVCL TRAPKPILHP PPVSKSDVKP VPGVPGVCRK TKKKHLKKSK NPEDVVRRYM QKVKNPPDED CTICMERLVT ASGYEGVLRH KGVRPELVGR LGRCGHMYHL LCLVAMYSNG NKDGSLQCPT CKAIYGEKTG TQPPGKMEFH LIPHSLPGFP DTQTIRIVYD IPTGIQGPEH PNPGKKFTAR GFPRHCYLPN NEKGRKVLRL LITAWERRLI FTIGTSNTTG ESDTVVWNEI HHKTEFGSNL TGHGYPDASY LDNVLAELTA QGVSEAAAKA
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
DTX1, or Deltex homolog 1, is a member of the Deltex family of proteins, which play a crucial role in the Notch signaling pathway, a fundamental mechanism governing cell fate decisions, differentiation, and development in multicellular organisms. Research into DTX1 has garnered attention due to its involvement in various biological processes, including immune responses, neural development, and the regulation of stem cell behavior. Dysregulation of Notch signaling, in which DTX1 is implicated, has been linked to several diseases, including cancers and neurodegenerative disorders, making it a significant target for therapeutic interventions. The characterization of DTX1 as a recombinantly expressed protein has advanced our understanding of its structure-function relationships and has facilitated investigations into its molecular interactions and regulatory roles within the Notch signaling pathway. Furthermore, studies suggest that DTX1 may play a role in modulating T-cell receptor signaling, indicating its potential impact on immune system function. As a result, the exploration of DTX1 recombinant protein promises not only to deepen our comprehension of cellular signaling mechanisms but also to pave the way for innovative strategies in treating diseases where the Notch pathway is disrupted. Continued research in this area could lead to the development of novel biomolecular tools and therapeutics aimed at modulating DTX1 activity for clinical benefit.
