Analytical Data
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基因名
SPCS1
- Application
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别名
HSPC033; Microsomal signal peptidase 12 kDa subunit; OTTHUMP00000206959; signal peptidase 12kDa; Signal peptidase complex subunit 1; signal peptidase complex subunit 1 homolog (S. cerevisiae); SPase 12 kDa subunit; SPC1; SPC12; SPCS1; SPCS1_HUMAN; YJR010C-A
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9Y6A9
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表达区间
1-104 aa
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氨基酸序列
MLEHLSSLPTQMDYKGQKLAEQMFQGIILFSAIVGFIYGYVAEQFGWTVYIVMAGFAFSCLAQLTLPPWPIYRRHPLKWLPVQESSTDDKKPGERKIKRHAKNN
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分子量
37.18 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
SPCS1 (Serine Palmitoyltransferase Subunit 1) is an enzyme that plays a crucial role in sphingolipid biosynthesis, a class of lipids essential for cellular membrane structure and signaling. The interest in SPCS1's function stems from its involvement in various physiological processes, including inflammation, cell growth, and apoptosis. Dysregulation of sphingolipid metabolism has been linked to several diseases, such as cancer, neurodegenerative disorders, and metabolic syndrome, making SPCS1 a potential therapeutic target. In recent studies, the recombinant expression of SPCS1 has allowed researchers to better understand its enzymatic mechanisms and interactions with other cellular components, providing insight into its regulatory role in sphingolipid metabolism. Additionally, characterization of SPCS1 through advanced biophysical techniques has revealed its structural properties, further elucidating how mutations in the SPCS1 gene can lead to functional impairments and associated pathologies. As research progresses, the recombinant SPCS1 protein is expected to facilitate drug discovery and the development of novel therapeutic strategies aimed at modulating sphingolipid signaling pathways in disease contexts.
