Analytical Data
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Gene name
ST8SIA3
- Application
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Alternative Names
ST8SIA3; SIAT8C; Sia-alpha-2.3-Gal-beta-1.4-GlcNAc-R:alpha 2.8-sialyltransferase; Alpha-2.8-sialyltransferase 8C; Alpha-2.8-sialyltransferase III; ST8 alpha-N-acetyl-neuraminide alpha-2.8-sialyltransferase 3; Sialyltransferase 8C; SIAT8-C; Sialyltransferase St8Sia III; ST8SiaIII
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O43173
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Expression Region
1-380 aa
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AA Sequence
MRNCKMARVASVLGLVMLSVALLILSLISYVSLKKENIFTTPKYASPGAPRMYMFHAGFRSQFALKFLDPSFVPITNSLTQELQEKPSKWKFNRTAFLHQRQEILQHVDVIKNFSLTKNSVRIGQLMHYDYSSHKYVFSISNNFRSLLPDVSPIMNKHYNICAVVGNSGILTGSQCGQEIDKSDFVFRCNFAPTEAFQRDVGRKTNLTTFNPSILEKYYNNLLTIQDRNNFFLSLKKLDGAILWIPAFFFHTSATVTRTLVDFFVEHRGQLKVQLAWPGNIMQHVNRYWKNKHLSPKRLSTGILMYTLASAICEEIHLYGFWPFGFDPNTREDLPYHYYDKKGTKFTTKWQESHQLPAEFQLLYRMHGEGLTKLTLSHCA
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Molecular Weight
70.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The ST8SIA3 protein, part of the ST8SIA gene family, is a significant player in the biosynthesis of polysialic acid, which is known to influence cell-cell interactions during neurodevelopment and in various pathological conditions. Alterations in polysialic acid expression, mediated by ST8SIA3, have been linked to neurodevelopmental disorders, including schizophrenia and autism spectrum disorders, as well as to tumor progression in certain cancers. Recent studies have highlighted the importance of this protein in modulating synaptic plasticity and neuronal migration, suggesting that it plays a critical role in brain development and function. As research advances, the potential of ST8SIA3 as a therapeutic target in neurodevelopmental and oncological contexts is also gaining attention. Understanding the structure and function of the ST8SIA3 recombinant protein could pave the way for innovative strategies in treating disorders associated with its dysregulation, making it a focal point of biomedical research.
