Analytical Data
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基因名
TMBIM6
- Application
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别名
TMBIM6; BI1; TEGT; Bax inhibitor 1; BI-1; Testis-enhanced gene transcript Protein; Transmembrane BAX inhibitor motif-containing Protein 6
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P55061
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表达区间
1-237 aa
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氨基酸序列
MNIFDRKINFDALLKFSHITPSTQQHLKKVYASFALCMLVAAAGAYVHMVTHFIQAGLLSALGSLILMIWLMATPHSHETEQKRLGLLAGFAFLTGVGLGPALEFCIAVNPSILPTAFMGTAMTFTCFTLSALYARRRSYLFLGGILMSALSLLLLSSLGNVFFGSIWLFQANLYVGLVVMCGFVLFDTQLIIEKAEHGDQDYIWHCIDLFLDFITVFRKLMMILAMNEKDKKKEKK
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分子量
51.81 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TMBIM6, a member of the TMBIM (Transmembrane BAX Inhibitor Motif-containing) family, has gained significant attention in the field of cellular biology due to its role in modulating apoptosis and cellular stress responses. This protein is primarily localized in the endoplasmic reticulum (ER) and is implicated in maintaining cellular homeostasis under stressful conditions, such as oxidative stress and nutrient deprivation. Recent studies have suggested that TMBIM6 exerts its functions by regulating calcium homeostasis and influencing mitochondrial dynamics, ultimately affecting cell survival and death pathways. The interest in TMBIM6 is driven by its potential implications in various diseases, including neurodegenerative disorders and cancers, where dysregulation of apoptosis plays a critical role. Moreover, exploring TMBIM6 as a therapeutic target could provide novel strategies for disease intervention. Consequently, the recombinant expression of TMBIM6 facilitates in-depth investigation of its functional properties and interactions within cellular contexts, enabling a better understanding of its biological significance and therapeutic potential. Researchers aim to elucidate the mechanistic pathways involving TMBIM6, thereby contributing to the broader understanding of ER-mediated signaling and its impact on cell fate decisions in health and disease.
