Analytical Data
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基因名
MLL4
- Application
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别名
Histone-lysine N-methyltransferase 2B. Lysine N-methyltransferase 2B. EC:2.1.1.364. Myeloid/lymphoid or mixed-lineage leukemia protein 4. Trithorax homolog 2. WW domain-binding protein 7. WBP-7
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q9UMN6
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表达区间
1487-1586 aa
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氨基酸序列
SKLEGMFPAYLQEAFFGKELLDLSRKALFAVGVGRPSFGLGTPKAKGDGGSERKELPTSQKGDDGPDIADEESRGLEGKADTPGPEDGGVKASPVPSDPE
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分子量
36.74 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MLL4, also known as KMT2D, is a critical member of the MLL family of histone methyltransferases, playing a significant role in the regulation of gene expression through histone modification. Mutations and dysregulation of MLL4 have been linked to several types of cancers, particularly in pediatric acute lymphoblastic leukemia and other hematological malignancies. The importance of MLL4 in normal hematopoiesis and its role as a tumor suppressor make it a compelling target for cancer research. Understanding the biochemical mechanisms by which MLL4 exerts its effects on chromatin remodeling and gene expression is essential for developing targeted therapies. Recent studies focus on producing recombinant MLL4 protein to investigate its enzymatic activity, interaction with other regulatory proteins, and impact on chromatin architecture. These investigations not only enhance our understanding of MLL4's role in oncogenesis but also pave the way for potential therapeutic strategies aimed at restoring normal function in MLL4-deficient cancers. Continued research into the structure-function relationship of MLL4 and its associated complexes promises to provide deeper insights into its biological significance and therapeutic potential.
