Analytical Data
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Gene name
HPS4
- Application
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Alternative Names
HPS4；KIAA1667；BLOC-3 complex member HPS4
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NQG7
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Expression Region
1-708aa
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AA Sequence
MATSTSTEAK SASWWNYFFL YDGSKVKEEG DPTRAGICYF YPSQTLLDQQ ELLCGQIAGV VRCVSDISDS PPTLVRLRKL KFAIKVDGDY LWVLGCAVEL PDVSCKRFLD QLVGFFNFYN GPVSLAYENC SQEELSTEWD TFIEQILKNT SDLHKIFNSL WNLDQTKVEP LLLLKAARIL QTCQRSPHIL AGCILYKGLI VSTQLPPSLT AKVLLHRTAP QEQRLPTGED APQEHGAALP PNVQIIPVFV TKEEAISLHE FPVEQMTRSL ASPAGLQDGS AQHHPKGGST SALKENATGH VESMAWTTPD PTSPDEACPD GRKENGCLSG HDLESIRPAG LHNSARGEVL GLSSSLGKEL VFLQEELDLS EIHIPEAQEV EMASGHFAFL HVPVPDGRAP YCKASLSASS SLEPTPPEDT AISSLRPPSA PEMLTQHGAQ EQLEDHPGHS SQAPIPRADP LPRRTRRPLL LPRLDPGQRG NKLPTGEQGL DEDVDGVCES HAAPGLECSS GSANCQGAGP SADGISSRLT PAESCMGLVR MNLYTHCVKG LVLSLLAEEP LLGDSAAIEE VYHSSLASLN GLEVHLKETL PRDEAASTSS TYNFTHYDRI QSLLMANLPQ VATPQDRRFL QAVSLMHSEF AQLPALYEMT VRNASTAVYA CCNPIQETYF QQLAPAARSS GFPNPQDGAF SLSGKAKQKL LKHGVNLL
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
HPS4, or Hermansky-Pudlak Syndrome 4, is a gene associated with a rare genetic disorder characterized by oculocutaneous albinism, prolonged bleeding due to platelet dysfunction, and a variety of other systemic issues. The protein encoded by HPS4 plays a crucial role in lysosomal function and the biogenesis of organelles involved in melanin production and platelet granule formation. Research into HPS4 recombinant protein is essential for understanding the molecular mechanisms underlying Hermansky-Pudlak Syndrome and the associated phenotypes. Studies have shown that mutations in the HPS4 gene disrupt normal cellular functions, leading to impaired trafficking of proteins necessary for melanosome and lysosome function. By producing and characterizing recombinant HPS4 protein, researchers aim to elucidate its structure-function relationship and explore how its dysfunction contributes to the clinical manifestations of the syndrome. Furthermore, understanding HPS4 can facilitate the development of potential therapeutic strategies for managing symptoms and improving the quality of life for affected individuals. The investigation of HPS4 protein dynamics also has broader implications for the study of other genetic disorders involving lysosomal and organelle dysfunction, making it a significant focus in both fundamental and applied biomedical research.
