Analytical Data
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基因名
CETP
- Application
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别名
CETP；Cholesteryl ester transfer Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P11597
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表达区间
1-493aa
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氨基酸序列
MLAATVLTLALLGNAHACSKGTSHEAGIVCRITKPALLVLNHETAKVIQT AFQRASYPDITGEKAMMLLGQVKYGLHNIQISHLSIASSQVELVEAKSID VSIQNVSVVFKGTLKYGYTTAWWLGIDQSIDFEIDSAIDLQINTQLTCDS GRVRTDAPDCYLSFHKLLLHLQGEREPGWIKQLFTNFISFTLKLVLKGQI CKEINVISNIMADFVQTRAASILSDGDIGVDISLTGDPVITASYLESHHK GHFIYKNVSEDLPLPTFSPTLLGDSRMLYFWFSERVFHSLAKVAFQDGRL MLSLMGDEFKAVLETWGFNTNQEIFQEVVGGFPSQAQVTVHCLKMPKISC QNKGVVVNSSVMVKFLFPRPDQQHSVAYTFEEDIVTTVQASYSKKKLFLS LLDFQITPKTVSNLTESSSESIQSFLQSMITAVGIPEVTSRLEVVFTALM NSKGVSLFDIINPEIITRDGFLLLQMDFGFPEHLLVDFLQSLS
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分子量
80 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CETP (Cholesteryl Ester Transfer Protein) is a key protein involved in lipid metabolism, specifically in the transfer of cholesteryl esters and triglycerides between lipoproteins. It plays a critical role in regulating cholesterol levels and is thus of great interest in cardiovascular research, particularly in relation to atherosclerosis and cardiovascular diseases. Studies have shown that variations in CETP activity can influence plasma lipid profiles and are associated with variations in cardiovascular risk. Given its central role in lipid transport and its potential as a therapeutic target, understanding the structure and function of CETP is crucial. Recombining CETP via recombinant DNA technology allows researchers to study its functionality in detail, enabling insights into its role in lipid metabolism and its potential implications for drug development. The production of recombinant CETP facilitates the exploration of its molecular mechanisms, interaction with other lipoproteins, and how it can be manipulated to improve lipid profiles in individuals at risk for heart disease. Thus, research on recombinant CETP is pivotal for elucidating its function and exploring new therapeutic strategies to manage dyslipidemia and reduce cardiovascular risks. Through advanced biotechnological methods and structural biology, the investigation of CETP continues to enhance our understanding of lipid metabolism and its broader implications for public health.
