Analytical Data
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Gene name
GP9
- Application
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Alternative Names
GP9；Platelet glycoProtein IX
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P14770
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Expression Region
1-177aa
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AA Sequence
MPAWGALFLLWATAEATKDCPSPCTCRALETMGLWVDCRGHGLTALPALPARTRHLLLANNSLQSVPPGAFDHLPQLQTLDVTQNPWHCDCSLTYLRLWLEDRTPEALLQVRCASPSLAAHGPLGRLTGYQLGSCGWQLQASWVRPGVLWDVALVAVAALGLALLAGLLCATTEALD
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Molecular Weight
19 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
The GP9 protein, a crucial component of the platelet membrane, is primarily involved in the adhesion of platelets to collagen during the hemostatic process. Its significance stems from its role in various blood disorders, including platelet function defects and bleeding disorders. Research has shown that GP9 is part of the glycoprotein family, specifically associated with the integrin receptor system, which plays a vital role in cell signaling and platelet aggregation. Understanding the structure and function of GP9 is essential for developing therapeutic strategies for conditions like Glanzmann's thrombasthenia and other thrombopathies. Recent studies have focused on the recombinant expression of GP9 to elucidate its functional characteristics and interactions with other platelet proteins. This recombinant protein serves as a valuable tool for investigating the molecular mechanisms underlying platelet activation and for screening potential inhibitors or modifiers that could improve platelet function in patients. The ongoing research into GP9, therefore, not only enhances our fundamental knowledge of platelet biology but also holds promise for innovative clinical applications in treating bleeding disorders.
