Analytical Data
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基因名
GJC1
- Application
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别名
GJC1; GJA7; Gap junction gamma-1 protein; Connexin-45; Cx45; Gap junction alpha-7 protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P36383
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表达区间
1-396aa
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氨基酸序列
MSWSFLTRLLEEIHNHSTFVGKIWLTVLIVFRIVLTAVGGESIYYDEQSKFVCNTEQPGCENVCYDAFAPLSHVRFWVFQIILVATPSVMYLGYAIHKIAKMEHGEADKKAARSKPYAMRWKQHRALEETEEDNEEDPMMYPEMELESDKENKEQSQPKPKHDGRRRIREDGLMKIYVLQLLARTVFEVGFLIGQYFLYGFQVHPFYVCSRLPCPHKIDCFISRPTEKTIFLLIMYGVTGLCLLLNIWEMLHLGFGTIRDSLNSKRRELEDPGAYNYPFTWNTPSAPPGYNIAVKPDQIQYTELSNAKIAYKQNKANTAQEQQYGSHEENLPADLEALQREIRMAQERLDLAVQAYSHQNNPHGPREKKAKVGSKAGSNKSTASSKSGDGKTSVWI
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分子量
45.4 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GJC1, or gap junction protein, alpha 1, is a member of the connexin family, which plays a crucial role in intercellular communication by forming gap junctions between adjacent cells. These gap junctions facilitate the exchange of ions and small molecules, thereby influencing various physiological processes, including cell growth, differentiation, and response to signals. Research on GJC1 has gained attention due to its association with several pathological conditions, particularly in the context of cardiac and neurological disorders. For instance, mutations in the GJC1 gene have been linked to conditions such as oculodentodigital dysplasia and have implications in the development of arrhythmias and neurological diseases. Investigating the structure and functionality of GJC1 is essential for understanding its role in health and disease, and it presents opportunities for developing therapeutic strategies targeting gap junction communication. Recent advances in molecular biology techniques, including recombinant protein expression, have enabled researchers to characterize GJC1 more effectively, providing insights into its functional mechanisms and interactions within cellular contexts. This knowledge is vital for unraveling the complexities of intercellular signaling and could lead to novel interventions in disease management, making GJC1 a significant focus in current biomedical research.
