Analytical Data
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Gene name
BMPR1A/ALK-3
- Application
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Alternative Names
CD292; ACVRLK3; ALK3; SKR5; BMPR1-A; Activin A Receptor, Type Ii-Like Kinase 3; Activin Receptor-Like Kinase 3; Serine/Threonine-Protein Kinase Receptor R5
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Species
Rat
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Source
E. coli
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Tag
N-His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
Q78EA7
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Expression Region
Gln24~Arg152
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Molecular Weight
17.92kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
BMPR1A (Bone Morphogenetic Protein Receptor Type 1A) and ALK-3 (Activin Receptor-Like Kinase 3) are integral components of the bone morphogenetic protein (BMP) signaling pathways, which play crucial roles in regulating various biological processes, including embryonic development, tissue homeostasis, and bone formation. Their dysregulation has been associated with a range of human diseases, including skeletal disorders and cancer. Research into BMPR1A/ALK-3 recombinant proteins has gained momentum due to their potential as therapeutic targets. Understanding the structure and function of these receptors is essential for deciphering their signaling mechanisms and exploring their implications in disease. Recombinant proteins allow for the detailed study of receptor interactions and downstream signaling cascades, providing valuable insights into the role of BMP signaling in cellular processes. Moreover, engineered variants of BMPR1A/ALK-3 can facilitate the development of novel biomaterials and regenerative medicine approaches, potentially leading to improved therapies for conditions caused by compromised BMP signaling. The ongoing investigation into these receptors aims not only to elucidate their functional roles but also to harness their signaling pathways for innovative treatment strategies in bone-related pathologies and other related disorders.
