Analytical Data
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Gene name
NBL1
- Application
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Alternative Names
NB; DAN; NO3; DAND1; Differential Screening-Selected Gene Aberrant In Neuroblastoma; DAN domain family member 1
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P41271
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Expression Region
Ala17~Asp181
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Molecular Weight
21kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
NBL1, a member of the transforming growth factor-beta (TGF-β) superfamily, plays a crucial role in various biological processes, including cell differentiation, proliferation, and apoptosis. Originally identified for its involvement in the development of structure formation in the embryo, recent studies have highlighted its significance in regulating immune responses and tissue homeostasis. The interest in NBL1 has surged due to its potential implications in cancer biology, where it may act as a tumor suppressor, as well as its involvement in neurodegenerative diseases and fibrosis. Researchers are particularly focused on the functional properties of NBL1 and the mechanism through which it exerts its effects at the cellular level. The production of recombinant NBL1 protein allows for detailed biochemical studies and the exploration of its interactions with various cellular components. This recombinant protein serves as an essential tool in elucidating the signaling pathways influenced by NBL1 and for developing potential therapeutic strategies targeting its pathways. Given the complexity of the TGF-β signaling network and the specific roles played by NBL1, ongoing research aims to uncover the precise molecular mechanisms and the biological context in which NBL1 operates. Understanding these factors is critical for harnessing the therapeutic potential of NBL1 in diseases where its function is disrupted.
