Analytical Data
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Gene name
DRD3
- Application
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Alternative Names
D(3) dopamine receptor; Dopamine D3 receptor; DRD3; Homo sapiens; Human; G-protein coupled receptor; Receptor; Transducer
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Species
Human
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Source
Baculovirus
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Tag
C-His;N-Flag
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P35462-1
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Expression Region
M1-K221,G319-C400, L119W
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Protein Length
Partial
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Molecular Weight
54.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Dopamine receptor D3 (DRD3) is a pivotal member of the dopamine receptor family, predominantly expressed in the brain's mesolimbic pathways. It plays a crucial role in modulating cognitive functions, emotional responses, and reward mechanisms. Research into DRD3 has garnered significant attention due to its involvement in various neuropsychiatric disorders, including schizophrenia and addiction, making it a potential target for therapeutic interventions. The exploration of recombinant DRD3 proteins is essential for understanding its structure-function relationships, signaling mechanisms, and interactions with various ligands. Studies have indicated that DRD3 exhibits unique characteristics compared to other dopamine receptors, such as distinct ligand-binding profiles and signaling cascades, which underline its therapeutic potential. Generating recombinant DRD3 proteins through techniques like recombinant DNA technology allows for the examination of its biophysical properties and the development of specific antagonists or agonists. This research not only enhances our understanding of DRD3’s role in neurobiology but also aids in the design of novel drugs targeting this receptor, offering hope for more effective treatments for disorders linked to dopamine dysregulation.
