Analytical Data
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Gene name
CCL16
- Application
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Alternative Names
SCYA16; SCYL4; LEC; HCC4; LMC; LCC1; CKb12; Mtn1; CC-4; Monotactin-1; IL-10-inducible chemokine; Liver-expressed chemokine; Lymphocyte and monocyte chemoattractant
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O15467
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Expression Region
Ala20~Gln120
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Molecular Weight
15kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CCL16, also known as liver and activation-regulated chemokine (LARC), is a notable member of the CC chemokine family, primarily recognized for its role in immune responses and inflammation. As a chemokine, CCL16 is involved in the recruitment of immune cells, particularly Th2 cells and eosinophils, to sites of inflammation, making it critical in various physiological and pathological processes, including allergic reactions, infectious diseases, and autoimmune conditions. Research indicates that CCL16 may play a significant role in modulating inflammatory responses, and its expression is often upregulated in conditions like asthma, chronic obstructive pulmonary disease (COPD), and certain cancers. The recombinant protein of CCL16 has gained attention for its potential applications in both basic research and therapeutic development. By studying the biochemical properties and functional mechanisms of CCL16, scientists aim to develop novel strategies to target inflammatory diseases, improve understanding of immune system dynamics, and explore its potential as a biomarker or therapeutic agent. The production and characterization of recombinant CCL16 protein facilitate a deeper investigation into its biological functions, interactions with receptors such as CCR4 and CCR8, and its influence on immune cell signaling pathways. This research holds promise for enhancing our knowledge of chemokines in immune regulation and offers insights into new treatment avenues for chronic inflammatory diseases.
