Analytical Data
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基因名
FKBP4
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简介
The FKBP4 protein is an immunophilin with peptidyl prolyl cis-trans isomerase (PPIase) and co-chaperone activity. It plays a key role in the formation of hybrids with steroid receptors, specifically by interacting with heat shock protein 90 (HSP90). FKBP4 Protein, Human (His) is the recombinant human-derived FKBP4 protein, expressed by E. coli , with C-6*His labeled tag.
- Application
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种属
Human
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表达系统
E. coli
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标签
C-6*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q02790
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表达区间
M1-A459
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氨基酸序列
MTAEEMKATESGAQSAPLPMEGVDISPKQDEGVLKVIKREGTGTEMPMIGDRVFVHYTGWLLDGTKFDSSLDRKDKFSFDLGKGEVIKAWDIAIATMKVGEVCHITCKPEYAYGSAGSPPKIPPNATLVFEVELFEFKGEDLTEEEDGGIIRRIQTRGEGYAKPNEGAIVEVALEGYYKDKLFDQRELRFEIGEGENLDLPYGLERAIQRMEKGEHSIVYLKPSYAFGSVGKEKFQIPPNAELKYELHLKSFEKAKESWEMNSEEKLEQSTIVKERGTVYFKEGKYKQALLQYKKIVSWLEYESSFSNEEAQKAQALRLASHLNLAMCHLKLQAFSAAIESCNKALELDSNNEKGLFRRGEAHLAVNDFELARADFQKVLQLYPNNKAAKTQLAVCQQRIRRQLAREKKLYANMFERLAEEENKAKAEASSGDHPTDTEMKEEQKSNTAGSQSQVETEA
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蛋白长度
Full Length
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分子量
50-60 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
FKBP4 (FK506-binding protein 4) is a member of the FKBP family of proteins, known for their protein-folding and chaperone activities, and plays a crucial role in regulating various cellular processes, including signal transduction, protein stability, and transport. In recent years, FKBP4 has garnered attention due to its involvement in stress responses and its potential implications in various diseases, such as cancer and neurodegenerative disorders. The protein interacts with numerous client proteins, including steroid hormone receptors and signaling molecules, thus influencing cellular pathways crucial for homeostasis and response to external stimuli. Moreover, FKBP4's role in the assembly and disassembly of multi-protein complexes makes it an interesting target for therapeutic interventions. The study of FKBP4 recombinant proteins is essential for understanding its structure-function relationship and the mechanisms underlying its chaperone activity. This research can offer insights into developing novel strategies for modulating FKBP4 activity in disease contexts, thereby contributing to advancements in targeted therapies. Understanding the biochemical properties of FKBP4, along with its interaction networks, could pave the way for innovative approaches in drug design and biomolecular research, particularly in diseases where protein misfolding or misregulation is prevalent. Consequently, the recombinant production of FKBP4 provides a vital tool for elucidating its functional roles in cellular physiology and pathology.
