Analytical Data
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Gene name
TP53AIP1
- Application
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Alternative Names
p53 regulated apoptosis inducing protein 1; p53-regulated apoptosis-inducing protein 1; P53AIP 1; p53AIP1; TP53AIP 1; TP53AIP1; TPIP1_HUMAN
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Species
Human
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Source
E. coli
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Tag
N- GST
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9HCN2
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Expression Region
1-108aa
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Molecular Weight
38.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
TP53AIP1, short for Tumor Protein p53 Regulator Associated with p53AIP1, is a protein that has gained attention in cancer research due to its interaction with the tumor suppressor protein p53. This protein plays a crucial role in regulating apoptosis and cell cycle arrest in response to DNA damage, thus contributing significantly to cellular responses to stress. Overexpression of TP53AIP1 has been linked to enhanced p53-mediated apoptosis, suggesting its potential role as a tumor suppressor. In various cancer types, alterations in the expression of TP53AIP1 may influence the effectiveness of p53 in regulating cellular growth and survival, highlighting its importance in tumorigenesis. Recent studies have focused on the molecular mechanisms by which TP53AIP1 influences p53 function and its implications for cancer therapy, particularly in understanding resistance mechanisms to chemotherapy. Researchers are exploring TP53AIP1's potential as a biomarker for cancer prognosis and as a target for therapeutic interventions aimed at restoring p53 activity in tumors that exhibit dysfunctional p53 signaling. The ongoing investigation into TP53AIP1 seeks to elucidate its precise role in the complex network of cellular stress responses and its therapeutic potential in transforming cancer treatment paradigms.
