Analytical Data
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Gene name
P2X3
- Application
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Alternative Names
P2X purinoceptor 3; ATP receptor; Purinergic receptor; P2RX3; Homo sapiens; Human; P2X3; Ion channel; Ligand-gated ion channel; Receptor
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Species
Human
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Source
HEK293
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Tag
Tag Free
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P56373
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Expression Region
D6-E363, T13P, S15V, V16I
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Protein Length
Partial
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Molecular Weight
40.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
P2X3 receptors, a subtype of the purinergic receptor family, are ATP-gated ion channels that play a crucial role in sensory signaling pathways, particularly in pain perception and nociception. The research surrounding recombinant P2X3 proteins has gained significant attention due to their involvement in various physiological and pathophysiological processes, including chronic pain conditions such as neuropathic pain and inflammatory pain. Understanding the structural and functional characteristics of P2X3 receptors is essential for the development of targeted therapeutics aimed at alleviating pain without the side effects associated with conventional analgesics. Recombinant expression systems allow for the production of P2X3 proteins in sufficient quantities for detailed biochemical and pharmacological studies, enabling researchers to dissect the receptor's mechanism of action, ligand binding properties, and ion conduction pathways. These studies are pivotal in identifying potential drug candidates that can selectively modulate P2X3 activity, thereby offering novel strategies for pain management. Furthermore, the characterization of P2X3 receptor functions may reveal insights into the broader purinergic signaling landscape, which has implications in various other diseases, including cancer and neurodegenerative disorders. Hence, ongoing research on recombinant P2X3 proteins is not only fundamental to pain neuroscience but also holds promise for advancing therapeutic approaches in multiple human health conditions.
