Analytical Data
-
Gene name
DCTN4
- Application
-
Alternative Names
Dynactin subunit p62
-
Species
Human
-
Source
Yeast
-
Tag
N- His
-
Purity
Greater than 90% as determined by SDS-PAGE.
-
Uniprot
Q9UJW0
-
Expression Region
2-460aa
-
Molecular Weight
54.2 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
The DCTN4 protein, a member of the Dynactin complex, plays a critical role in intracellular transport and cytoskeletal dynamics by interacting with dynein motors and aiding in the retrograde transport of vesicles and organelles. Dysregulation of DCTN4 has been implicated in various neurodegenerative diseases, such as Amyotrophic Lateral Sclerosis (ALS) and Alzheimer's disease, where impaired axonal transport contributes to neuronal dysfunction. Recent studies have highlighted the importance of DCTN4 in maintaining cellular homeostasis and its potential interactions with other proteins involved in cellular signaling pathways. Given its significant role in cellular transport mechanisms, researchers are focusing on characterizing the structural and functional properties of recombinant DCTN4 protein to better understand its function and the consequences of its dysregulation. This includes examining its binding activities, post-translational modifications, and interactions with other dynactin components. Understanding the functional implications of DCTN4 could provide insights into novel therapeutic strategies for neurodegenerative diseases, whereby enhancing or restoring its activity may mitigate the transport-related deficits observed in affected neurons. Overall, the study of DCTN4 recombinant protein stands to illuminate the intricate relationships between cytoskeletal dynamics and neurodegeneration, paving the way for potential interventions in related pathologies.
