Analytical Data
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基因名
RNF128
- Application
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别名
GRAIL; Gene related to anergy in lymphocytes protein; E3 ubiquitin-protein ligase RNF128
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种属
Human
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表达系统
E. coli
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标签
N-His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q8TEB7
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表达区间
Ala39~Ser207
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分子量
22kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RNF128, also known as TRIM32, is a member of the tripartite motif (TRIM) protein family, involved in various cellular processes, including ubiquitination, transcriptional regulation, and protein stability. This protein has garnered significant attention due to its role in modulating immune responses, particularly in the context of viral infections and autoimmune diseases. Recent studies have highlighted its involvement in regulating signaling pathways, such as the NF-κB pathway, which is crucial for inflammatory responses. RNF128's E3 ubiquitin ligase activity allows it to target specific substrates for degradation, thereby influencing cellular homeostasis and immune activation. Understanding the structure and function of recombinant RNF128 is pivotal for unraveling its biological roles and therapeutic potential. Researchers are particularly interested in characterizing its interactions with other proteins in the immune system and exploring its potential as a biomarker for diseases related to immune dysregulation. As a result, the development of RNF128 recombinant proteins provides valuable tools for further investigation into its signaling pathways and cellular functions, paving the way for innovative therapeutic strategies in treating inflammatory and autoimmune disorders.
