Analytical Data
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Gene name
RNF128
- Application
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Alternative Names
GRAIL; Gene related to anergy in lymphocytes protein; E3 ubiquitin-protein ligase RNF128
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8TEB7
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Expression Region
Ala39~Ser207
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Molecular Weight
22kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
RNF128, also known as TRIM32, is a member of the tripartite motif (TRIM) protein family, involved in various cellular processes, including ubiquitination, transcriptional regulation, and protein stability. This protein has garnered significant attention due to its role in modulating immune responses, particularly in the context of viral infections and autoimmune diseases. Recent studies have highlighted its involvement in regulating signaling pathways, such as the NF-κB pathway, which is crucial for inflammatory responses. RNF128's E3 ubiquitin ligase activity allows it to target specific substrates for degradation, thereby influencing cellular homeostasis and immune activation. Understanding the structure and function of recombinant RNF128 is pivotal for unraveling its biological roles and therapeutic potential. Researchers are particularly interested in characterizing its interactions with other proteins in the immune system and exploring its potential as a biomarker for diseases related to immune dysregulation. As a result, the development of RNF128 recombinant proteins provides valuable tools for further investigation into its signaling pathways and cellular functions, paving the way for innovative therapeutic strategies in treating inflammatory and autoimmune disorders.
