Analytical Data
-
Gene name
S100A14
-
简介
The S100A14 protein, encoded by a gene on chromosome 1, is a member of the S100 protein family with calcium-binding ability. It shows decreased levels in cancerous tissue, suggesting a potential tumor suppressor role and association with metastasis. S100A14 exhibits biased expression in the esophagus (RPKM 798.1), skin (RPKM 171.2), and other tissues, indicating its potential significance in these contexts. S100A14 Protein, Human (His, solution) is the recombinant human-derived S100A14 protein, expressed by E. coli , with N-His labeled tag.
- Application
-
Alternative Names
Protein S100-A14; S100 calcium-binding protein A14; S114; S100A14; S100A15
-
Species
Human
-
Source
E. coli
-
Tag
N-His
-
Purity
Greater than 95% as determined by SDS-PAGE.
-
Uniprot
NP_065723.1
-
Expression Region
G2-H104
-
Protein Length
Full Length of Mature Protein
-
Molecular Weight
12 kDa
-
Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
-
Form
Freeze-dried powder
-
Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
-
Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
-
Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
-
Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
-
Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
S100A14 is a member of the S100 protein family, known for its role in various cellular processes, including cell differentiation, migration, and apoptosis. This calcium-binding protein is predominantly expressed in epithelial tissues and has been implicated in several pathological conditions, including cancer. Research has shown that S100A14 can influence tumor progression and metastasis, making it a potential biomarker for cancer diagnosis and prognosis. Additionally, its involvement in inflammatory responses highlights its relevance in diseases characterized by chronic inflammation. The interest in recombinant S100A14 protein is driven by the need to understand its biological functions in greater detail, as well as its potential therapeutic applications. Producing recombinant S100A14 allows for the examination of its structural and functional properties in controlled experimental settings. Furthermore, studying S100A14's interactions with other proteins can illuminate its role in signaling pathways and cellular mechanisms. As a result, S100A14 has emerged as an important target for research aimed at developing novel diagnostic tools and therapeutic strategies for cancer and inflammatory diseases. Understanding its mechanism of action and modulation in various biological contexts can ultimately contribute to more effective treatment approaches and improve patient outcomes.
