Analytical Data
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Gene name
DOC2b
- Application
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Alternative Names
DOC2BL; Double C2-like domain-containing protein beta
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Species
Human
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Source
E. coli
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Tag
N-His
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q14184
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Expression Region
Gly173~Asp412
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Molecular Weight
31kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
DOC2b, or document 2b, is a protein that plays a critical role in neuronal communication and synaptic function. As part of the DOC family, DOC2b is involved in calcium-dependent exocytosis, influencing neurotransmitter release in neurons. Research into DOC2b has been driven by its potential implications in understanding various neurological disorders, including autism, schizophrenia, and other synaptic dysfunctions. Studies have shown that DOC2b is associated with synaptic vesicles and interacts with other proteins to facilitate the docking and fusion of vesicles at the synapse in response to calcium influx. Given the importance of synaptic plasticity in learning and memory, investigating the functional mechanisms of DOC2b may offer insights into its role in these processes. Advances in molecular biology and biochemistry have allowed for the exploration of DOC2b's structure, function, and interaction networks, paving the way for potential therapeutic strategies targeting synaptic modulation. Furthermore, the study of DOC2b can also contribute to the broader understanding of calcium signaling in excitable cells. As researchers continue to elucidate the complexities of DOC2b, it remains a significant focus within neuroscience, with the hope of unraveling new avenues for treating synaptic-related disorders.
