Analytical Data
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基因名
MICA
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简介
MHC class I chain-related protein A (MICA) is a highly polymorphic major histocompatability complex class I chain-related protein A. MICA is expressed on the cell surface and is a ligand for the NKG2-D type II integral membrane protein receptor and functions as a stress-induced antigen that is broadly recognized by intestinal epithelial gamma delta T cells, MICA has been associated with susceptibility to psoriasis 1 and psoriatic arthritis. MICA Protein, Human (HEK293, His-Avi) is the recombinant human-derived MICA protein, expressed by HEK293 , with C-Avi, C-His labeled tag.
- Application
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别名
FLJ60820; MGC111087; MICA; PERB11.1; DAMA-345G11.2; FLJ36918; FLJ60820; MGC21250
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种属
Human
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表达系统
HEK293
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标签
C-Avi;C-8*His
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q96QC4
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表达区间
E24-Q308
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蛋白长度
Partial
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分子量
55-70 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
MICA (MHC class I polypeptide-related sequence A) is a protein that plays a crucial role in the immune system by acting as a ligand for the NKG2D receptor found on natural killer (NK) cells and some T cells. Research into MICA has gained significant attention due to its involvement in the regulation of immune responses, particularly in tumor immunity and autoimmune diseases. MICA is often upregulated in stressed, infected, or malignant cells, allowing the immune system to recognize and eliminate these abnormal cells. However, its overexpression can also contribute to immune evasion by tumors, leading to poor prognosis in cancer patients. The study of recombinant MICA proteins has facilitated investigations into their structural properties, biological functions, and interactions with other immune components, providing insights into their potential therapeutic applications. Understanding MICA's role in immune modulation has opened avenues for developing novel immunotherapies aimed at enhancing anti-tumor responses or mitigating autoimmune conditions. Additionally, research on MICA polymorphisms and their influence on individual susceptibility to diseases further underscores its importance in immunogenetics. Overall, MICA's multifaceted involvement in immune regulation makes it a significant target for research in immunology and therapeutic development.
