Analytical Data
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Gene name
ACKR3
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简介
ACKR3 is an atypical chemokine receptor that precisely controls chemokine levels and localization through high-affinity binding, operating independently of ligand-driven signaling. It acts as an interceptor, internalization receptor, and chemokine scavenger for CXCL11 and CXCL12/SDF1, inducing β-arrestin recruitment, ligand internalization, and MAPK pathway activation. ACKR3 Protein, Human (His-SUMO) is the recombinant human-derived ACKR3 protein, expressed by E. coli , with N-SUMO, N-6*His labeled tag.
- Application
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Alternative Names
RDC1; CXCR7; RDC-1; CMKOR1; CXC-R7; CXCR-7; GPR159;
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Species
Human
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Source
E. coli
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Tag
N-SUMO;N-6*His
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Purity
Greater than 95% as determined by SDS-PAGE.
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Uniprot
P25106
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Expression Region
M1-K40
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Protein Length
Extracellular Domain
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Molecular Weight
27 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ACKR3, or atypical chemokine receptor 3, is a member of the chemokine receptor family and plays a crucial role in modulating immune responses and inflammatory processes. This receptor is known to bind various chemokines, including CXCL11 and CXCL12, and has been implicated in numerous physiological and pathological conditions, such as cancer progression, tissue repair, and immune cell trafficking. Unlike conventional chemokine receptors, ACKR3 operates mainly as a scavenger, internalizing chemokines and regulating their availability within the extracellular environment, thereby influencing cell migration and activation. Recent studies have highlighted its significance in promoting tumor growth and metastasis, making it a potential therapeutic target in oncology. Investigating ACKR3 as a recombinant protein offers insights into its structure-function relationships, signaling pathways, and interaction with other molecules. This research can pave the way for the development of targeted therapies aimed at modulating ACKR3 activity, with implications for treating various diseases, including cancer and chronic inflammatory conditions. By generating and characterizing ACKR3 recombinant proteins, scientists aim to elucidate its role in pathology and discover novel strategies for intervention.
