Analytical Data
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基因名
ACKR3
- Application
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别名
C-X-C chemokine receptor type 7 Short name: CXC-R7 Short name: CXCR-7 Chemokine orphan receptor 1 G-protein coupled receptor 159 G-protein coupled receptor RDC1 homolog Short name: RDC-1
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P25106
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表达区间
1-362aa
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分子量
57.5 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ACKR3, or atypical chemokine receptor 3, is a member of the chemokine receptor family and plays a crucial role in modulating immune responses and inflammatory processes. This receptor is known to bind various chemokines, including CXCL11 and CXCL12, and has been implicated in numerous physiological and pathological conditions, such as cancer progression, tissue repair, and immune cell trafficking. Unlike conventional chemokine receptors, ACKR3 operates mainly as a scavenger, internalizing chemokines and regulating their availability within the extracellular environment, thereby influencing cell migration and activation. Recent studies have highlighted its significance in promoting tumor growth and metastasis, making it a potential therapeutic target in oncology. Investigating ACKR3 as a recombinant protein offers insights into its structure-function relationships, signaling pathways, and interaction with other molecules. This research can pave the way for the development of targeted therapies aimed at modulating ACKR3 activity, with implications for treating various diseases, including cancer and chronic inflammatory conditions. By generating and characterizing ACKR3 recombinant proteins, scientists aim to elucidate its role in pathology and discover novel strategies for intervention.
