Analytical Data
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Gene name
HUS1
- Application
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Alternative Names
Checkpoint protein HUS1; hHUS1; HUS1 (S. pombe) checkpoint homolog; Hus1; HUS1 checkpoint homolog (S. pombe); HUS1 Checkpoint Protein; HUS1 protein; HUS1+ - like protein; HUS1_HUMAN; Hydroxyurea-sensitive 1, S. pombe, homolog of
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
O60921
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Expression Region
2-280aa
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Molecular Weight
47.6 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HUS1 is a crucial protein involved in the DNA damage response and cell cycle regulation, playing a vital role in maintaining genomic stability. Research on HUS1 has gained momentum due to its significance in various biological processes, including DNA repair, checkpoint activation, and apoptosis. HUS1 is a component of the 9-1-1 complex, which is essential for activating ATM and ATR signaling pathways in response to DNA damage. Alterations in HUS1 expression and function have been implicated in cancer development, making it a potential target for therapeutic interventions. Furthermore, studies have shown that HUS1 is involved in the maintenance of telomeres and the prevention of chromosome end fusions, further underscoring its importance in cellular health and longevity. Understanding the molecular mechanisms underlying HUS1 function can provide insights into the pathways that safeguard against genomic instability and contribute to tumorigenesis. Current research efforts are focusing on characterizing HUS1's structure, its protein interactions, and its regulatory mechanisms, potentially paving the way for novel cancer therapies and enhancing our knowledge of the broader implications of DNA damage response pathways in human health.
