Analytical Data
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Gene name
ID1
- Application
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Alternative Names
Class B basic helix-loop-helix protein 24 ;bHLHb24Inhibitor of DNA binding 1Inhibitor of differentiation 1
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P41134
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Expression Region
1-155aa
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Molecular Weight
32.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
ID1 (Inhibitor of DNA Binding 1) is a helix-loop-helix protein that plays a critical role in regulating cell differentiation and development, particularly in the context of stem cell biology and cancer. Research into ID1 has gained momentum due to its involvement in various signaling pathways, including those linked to cellular proliferation and survival. High levels of ID1 expression have been associated with aggressive forms of cancer, making it a potential biomarker for disease progression and a target for therapeutic interventions. Studies show that ID1 can inhibit the transcriptional activity of basic helix-loop-helix factors, thereby modulating the balance between cell proliferation and differentiation. Its role in the epithelial-mesenchymal transition (EMT), a process critical for metastasis, further underscores its significance in cancer research. Moreover, ID1 has been investigated for its potential functions in stem cell maintenance, suggesting its importance in regenerative medicine. Consequently, understanding the molecular mechanisms underlying ID1 expression and function could provide insights into novel strategies for cancer treatment and stem cell therapy. The ongoing research in this area aims to elucidate the pathways governing ID1 activity, its interactions with other proteins, and its overall impact on cellular behavior in both normal and pathological contexts. This comprehensive understanding may pave the way for innovative approaches to inhibit tumor progression and enhance stem cell applications.
