Analytical Data
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基因名
INMT
- Application
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别名
Aromatic alkylamine N-methyltransferase ;Amine N-methyltransferase ;Arylamine N-methyltransferaseThioether S-methyltransferase ;TEMT
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种属
Human
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O95050
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表达区间
1-263aa
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分子量
44.9 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
INMT (Indolethylamine N-methyltransferase) is an essential enzyme involved in the biosynthesis of biologically active compounds such as neurotransmitters and indole derivatives. This enzyme catalyzes the N-methylation of indoleamine substrates, playing a crucial role in the metabolism of serotonin and other tryptophan derivatives. Dysregulation of INMT has been implicated in various neurological and psychiatric disorders, making it a significant target for research in medicinal chemistry and neurobiology. Recent studies have explored the potential of recombinant INMT proteins for therapeutic applications, as well as their role in elucidating metabolic pathways associated with indole compounds. The advancement of recombinant DNA technology has facilitated the production and characterization of INMT, enabling systematic investigations into its enzymatic properties and regulatory mechanisms. Understanding the structure-function relationship of INMT through recombinant protein studies could illuminate its role in human health and disease, paving the way for novel pharmacological strategies aimed at modulating its activity for therapeutic benefit. The ongoing research endeavors emphasize the importance of INMT as a vital component of the biochemical landscape and its potential exploitation in drug discovery and development.
