Analytical Data
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Gene name
Nkx2-2
- Application
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Alternative Names
Homeobox protein NK-2 homolog B
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Species
Mouse
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
P42586
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Expression Region
1-273aa
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Molecular Weight
46.1 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Nkx2-2 is a transcription factor that plays a critical role in the development and function of various tissues, particularly in the central nervous system and pancreatic islets. It is essential for the differentiation of oligodendrocyte precursor cells and has been implicated in the regulation of insulin-producing beta cells. Abnormal expression of Nkx2-2 has been linked to neurological disorders and metabolic diseases, suggesting its potential as a therapeutic target. The study of Nkx2-2 recombinant protein is vital for understanding its function in embryonic development and cellular reprogramming. Researchers utilize recombinant Nkx2-2 to investigate its molecular mechanisms, interactions with other proteins, and downstream effects in cellular pathways. Additionally, producing Nkx2-2 as a recombinant protein allows for high-purity samples that facilitate various biochemical assays and functional studies needed to decipher its role in disease contexts. Advances in recombinant DNA technology have enabled the generation of Nkx2-2 proteins with specific modifications, enhancing the understanding of its structure-function relationships and paving the way for potential applications in regenerative medicine and gene therapy. Overall, the exploration of Nkx2-2 recombinant protein is crucial for uncovering its biological significance and therapeutic potential in treating conditions associated with its dysregulation.
