Analytical Data
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基因名
Nkx2-2
- Application
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别名
Homeobox protein NK-2 homolog B
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种属
Mouse
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表达系统
E. coli
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标签
N- His-SUMO
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P42586
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表达区间
1-273aa
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分子量
46.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Nkx2-2 is a transcription factor that plays a critical role in the development and function of various tissues, particularly in the central nervous system and pancreatic islets. It is essential for the differentiation of oligodendrocyte precursor cells and has been implicated in the regulation of insulin-producing beta cells. Abnormal expression of Nkx2-2 has been linked to neurological disorders and metabolic diseases, suggesting its potential as a therapeutic target. The study of Nkx2-2 recombinant protein is vital for understanding its function in embryonic development and cellular reprogramming. Researchers utilize recombinant Nkx2-2 to investigate its molecular mechanisms, interactions with other proteins, and downstream effects in cellular pathways. Additionally, producing Nkx2-2 as a recombinant protein allows for high-purity samples that facilitate various biochemical assays and functional studies needed to decipher its role in disease contexts. Advances in recombinant DNA technology have enabled the generation of Nkx2-2 proteins with specific modifications, enhancing the understanding of its structure-function relationships and paving the way for potential applications in regenerative medicine and gene therapy. Overall, the exploration of Nkx2-2 recombinant protein is crucial for uncovering its biological significance and therapeutic potential in treating conditions associated with its dysregulation.
