Analytical Data
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Gene name
PYCR1
- Application
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Alternative Names
/
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Species
Human
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Source
E. coli
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Tag
N- His-SUMO
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8TBX0
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Expression Region
1-171aa
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Molecular Weight
33.7 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
PYCR1, or Pyrroline-5-Carboxylate Reductase 1, is an enzyme that plays a crucial role in the proline biosynthesis pathway, contributing to cellular responses to stress, tumors, and metabolic disorders. It is involved in converting pyrroline-5-carboxylate to proline, a key amino acid that functions as an osmoprotectant and stabilizer of protein structures under conditions of oxidative and osmotic stress. Elevated levels of proline have been implicated in tumorigenesis, as cancer cells often exploit this pathway for enhanced survival and growth in harsh environments. Recent studies have highlighted the significance of PYCR1 in various cancers, linking its overexpression to poor prognosis and resistance to therapy, making it an attractive target for therapeutic intervention. Additionally, PYCR1 is associated with certain genetic disorders, underlining its importance in metabolic regulation. Research on PYCR1 encompasses its biochemical properties, regulatory mechanisms, and potential as a biomarker or therapeutic target in cancer and metabolic diseases, indicating its relevance in understanding cellular metabolism and signaling pathways. As such, ongoing studies are aimed at elucidating the diverse roles of PYCR1 in health and disease, paving the way for innovations in targeted therapies and metabolic disorder management.
