Analytical Data
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基因名
CDK2AP1
- Application
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别名
CDK2AP1;CDKAP1;DOC1;Cyclin-dependent kinase 2-associated Protein 1
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O14519-1
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表达区间
1-115aa
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氨基酸序列
MRGSHHHHHH GMASMTGGQQ MGRDLYDDDD KDRWGSHMSY KPNLAAHMPA AALNAAGSVH SPSTSMATSS QYRQLLSDYG PPSLGYTQGT GNSQVPQSKY AELLAIIEEL GKEIRPTYAG SKSAMERLKR GIIHARGLVR ECLAETERNA RS
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分子量
17 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
CDK2AP1 (Cyclin-Dependent Kinase 2-Associated Protein 1) is a protein that has garnered attention in recent years due to its role in cell cycle regulation and its potential implications in cancer biology. As a regulator of cyclin-dependent kinases (CDKs), CDK2AP1 is involved in controlling the transition between different phases of the cell cycle, particularly influencing the progression through the G1 to S phase. Its expression levels and activity are often altered in various cancers, suggesting that it may function as a tumor suppressor. Studies have indicated that CDK2AP1 can inhibit cell proliferation and induce apoptosis in some cancer cell lines, making it a potential target for therapeutic strategies aimed at restoring its function in malignant cells. Additionally, the protein's involvement in cellular stress responses and its interactions with other key regulatory proteins further highlight its importance in maintaining cellular homeostasis. The exploration of CDK2AP1 as a recombinant protein has also opened new avenues for biochemical studies, allowing researchers to dissect its functional mechanisms and the pathways it regulates. Investigating CDK2AP1 and its effects on tumor biology not only enhances our understanding of cancer progression but also may lead to the development of innovative approaches for cancer treatment and prevention. As research advances, the significance of CDK2AP1 in the context of cell cycle regulation and tumorigenesis continues to be a promising area of investigation.












