Analytical Data
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Gene name
NAIP
- Application
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Alternative Names
NAIP；BIRC1；Baculoviral IAP repeat-containing Protein 1
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q13075
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Expression Region
60-345aa
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AA Sequence
EAKRLKTFVTYEPYSSWIPQEMAAAGFYFTGVKSGIQCFCCSLILFGAGLTRLPIEDHKRFHPDCGFLLNKDVGNIAKYDIRVKNLKSRLRGGKMRYQEEEARLASFRNWPFYVQGISPCVLSEAGFVFTGKQDTVQCFSCGGCLGNWEEGDDPWKEHAKWFPKCEFLRSKKSSEEITQYIQSYKGFVDITGEHFVNSWVQRELPMASAYCNDSIFAYEELRLDSFKDWPRESAVGVAALAKAGLFYTGIKDIVQCFSCGGCLEKWQEGDDPLDDHTRCFPNCPFL
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Molecular Weight
48.6kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
NAIP (Neuronal Apoptosis Inhibitory Protein) is a member of the Birc (Baculoviral IAP Repeat Containing) family and plays a crucial role in the regulation of apoptosis, particularly in neuronal cells. Research into NAIP has gained traction due to its involvement in neuroprotection and its potential implications in neurodegenerative diseases, such as amyotrophic lateral sclerosis (ALS) and spinal muscular atrophy (SMA). The protein functions as an inhibitor of apoptosis by binding to caspases, thereby preventing the induction of programmed cell death in neurons. Moreover, NAIP has been associated with the modulation of inflammation and innate immune responses, suggesting it may have broader biological roles. Recent advancements in recombinant protein technology have enabled the production of functional NAIP for detailed biochemical studies and potential therapeutic applications. Understanding NAIP's structure and function could provide insights into its mechanistic roles in neuronal survival and its potential as a target for drug development in treating neurodegenerative disorders. As a result, research on NAIP not only contributes to our understanding of fundamental cellular processes but also paves the way for innovative therapeutic strategies aimed at enhancing neuronal resilience and combating neurodegeneration.
