Analytical Data
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基因名
RRAGA
- Application
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别名
RRAGA；Ras-related GTP-binding Protein A
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q7L523
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表达区间
1-247aa
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氨基酸序列
MPNTAMKKKVLLMGKSGSGKTSMRSIIFANYIARDTRRLGATIDVEHSHVRFLGNLVLNLWDCGGQDTFMENYFTSQRDNIFRNVEVLIYVFDVESRELEKDMHYYQSCLEAILQNSPDAKIFCLVHKMDLVQEDQRDLIFKEREEDLRRLSRPLECACFRTSIWDETLYKAWSSIVYQLIPNVQQLEMNLRNFAQIIEADEVLLFERATFLVISHYQCKEQRDVHRFEKISNIIKQFKLSCSKLAA
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分子量
56.1 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
RRAGA (Ras-related GTPase A) is a member of the RAS superfamily, which plays a crucial role in various cellular processes, including cell growth, differentiation, and metabolism. Research on RRAGA has garnered significant attention due to its involvement in mTOR (mechanistic target of rapamycin) signaling pathways, which are pivotal in regulating cellular responses to nutrient availability and stress. Dysregulation of mTOR signaling has been linked to a range of diseases, including cancer, obesity, and metabolic disorders. Furthermore, RRAGA has been identified as a key regulator of autophagy, a cellular degradation process that is essential for maintaining cellular homeostasis. The study of RRAGA and its interactions with other proteins offers potential insights into therapeutic targets for diseases where mTOR signaling and autophagy are disrupted. As a result, recombinant proteins of RRAGA are being explored to elucidate its structural and functional properties, facilitating a better understanding of its role in cellular signaling pathways. This research not only highlights the biological significance of RRAGA but also provides a foundation for developing novel interventions aimed at modulating its activity in relevant disease contexts.
