Analytical Data
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Gene name
CSF3R
- Application
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Alternative Names
CSF3R；GCSFR；Granulocyte colony-stimulating factor receptor
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q99062
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Expression Region
25-621aa
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AA Sequence
ECGHISVSAPIVHLGDPITASCIIKQNCSHLDPEPQILWRLGAELQPGGRQQRLSDGTQESIITLPHLNHTQAFLSCCLNWGNSLQILDQVELRAGYPPAIPHNLSCLMNLTTSSLICQWEPGPETHLPTSFTLKSFKSRGNCQTQGDSILDCVPKDGQSHCCIPRKHLLLYQNMGIWVQAENALGTSMSPQLCLDPMDVVKLEPPMLRTMDPSPEAAPPQAGCLQLCWEPWQPGLHINQKCELRHKPQRGEASWALVGPLPLEALQYELCGLLPATAYTLQIRCIRWPLPGHWSDWSPSLELRTTERAPTVRLDTWWRQRQLDPRTVQLFWKPVPLEEDSGRIQGYVVSWRPSGQAGAILPLCNTTELSCTFHLPSEAQEVALVAYNSAGTSRPTPVVFSESRGPALTRLHAMARDPHSLWVGWEPPNPWPQGYVIEWGLGPPSASNSNKTWRMEQNGRATGFLLKENIRPFQLYEIIVTPLYQDTMGPSQHVYAYSQEMAPSHAPELHLKHIGKTWAQLEWVPEPPELGKSPLTHYTIFWTNAQNQSFSAILNASSRGFVLHGLEPASLYHIHLMAASQAGATNSTVLTLMTLTP
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Molecular Weight
69.8 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
CSF3R (Colony Stimulating Factor 3 Receptor) is a critical receptor involved in hematopoiesis, specifically influencing the proliferation and differentiation of granulocyte lineage cells. Mutations in the CSF3R gene have been linked to various blood disorders, including chronic neutrophilic leukemia (CNL) and congenital neutropenia, underscoring its significance in myeloid progenitor cell regulation. Research on CSF3R recombinant proteins aims to better understand the receptor's structure, function, and interactions with its ligand, granulocyte colony-stimulating factor (G-CSF). By producing recombinant CSF3R, scientists can investigate its role in cellular signaling pathways and its impact on myeloid cell function. This research not only enhances our comprehension of normal hematopoiesis but also contributes to the development of targeted therapies for related hematological conditions. Moreover, studies on CSF3R can shed light on the mechanisms of receptor activation and potential therapeutic interventions for disorders caused by aberrations in the CSF3R pathway. Overall, the exploration of CSF3R recombinant protein serves as a vital step towards elucidating the complexities of myeloid differentiation and addressing the challenges posed by related diseases.
