Analytical Data
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Gene name
KAE1
- Application
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Alternative Names
KAE1；tRNA N6-adenosine threonylcarbamoyltransferase
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NPF4
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Expression Region
1-335aa
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AA Sequence
MPAVLGFEGSANKIGVGVVRDGKVLANPRRTYVTPPGTGFLPGDTARHHRAVILDLLQEALTESGLTSQDIDCIAYTKGPGMGAPLVSVAVVARTVAQLWNKPLVGVNHCIGHIEMGRLITGATSPTVLYVSGGNTQVIAYSEHRYRIFGETIDIAVGNCLDRFARVLKISNDPSPGYNIEQMAKRGKKLVELPYTVKGMDVSFSGILSFIEDVAHRMLATGECTPEDLCFSLQETVFAMLVEITERAMAHCGSQEALIVGGVGCNVRLQEMMATMCQERGARLFATDERFCIDNGAMIAQAGWEMFRAGHRTPLSDSGVTQRYRTDEVEVTWRD
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Molecular Weight
63.4 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
Related Products
Protein Description
KAE1 (KAT6-interacting protein 1) is a member of the KAT6 family of histone acetyltransferases, which play critical roles in regulating gene expression through chromatin remodeling. Research has highlighted the importance of KAE1 in various biological processes, including cell differentiation, proliferation, and response to stress. Abnormalities in KAE1 expression and function have been linked to several diseases, particularly cancer, where altered acetylation patterns can lead to oncogene activation or tumor suppressor gene repression. To better understand the mechanisms by which KAE1 influences these processes, scientists are focusing on the characterization and functional analysis of recombinant KAE1 proteins. This approach facilitates the elucidation of KAE1's catalytic activity, interactions with other essential proteins, and its role in histone modification pathways. Additionally, studying the recombinant protein allows researchers to explore potential therapeutic targets for diseases associated with dysregulated KAE1 function, thereby contributing to the development of novel strategies in cancer treatment and other disorders.
