Analytical Data
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Gene name
GPR83
- Application
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Alternative Names
GPR83; GPR72; KIAA1540; Probable G-protein coupled receptor 83; G-protein coupled receptor 72
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Species
Human
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Source
E. coli
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Tag
His tag N-Terminus
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q9NYM4
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Expression Region
1-423aa
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AA Sequence
MVPHLLLLCLLPLVRATEPHEGRADEQSAEAALAVPNASHFFSWNNYTFSDWQNFVGRRRYGAESQNPTVKALLIVAYSFIIVFSLFGNVLVCHVIFKNQRMHSATSLFIVNLAVADIMITLLNTPFTLVRFVNSTWIFGKGMCHVSRFAQYCSLHVSALTLTAIAVDRHQVIMHPLKPRISITKGVIYIAVIWTMATFFSLPHAICQKLFTFKYSEDIVRSLCLPDFPEPADLFWKYLDLATFILLYILPLLIISVAYARVAKKLWLCNMIGDVTTEQYFALRRKKKKTIKMLMLVVVLFALCWFPLNCYVLLLSSKVIRTNNALYFAFHWFAMSSTCYNPFIYCWLNENFRIELKALLSMCQRPPKPQEDRPPSPVPSFRVAWTEKNDGQRAPLANNLLPTSQLQSGKTDLSSVEPIVTMS
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Molecular Weight
48.3 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GPR83, or G protein-coupled receptor 83, is an evolutionary conserved receptor that has garnered attention in recent years due to its involvement in various physiological processes and potential implications in pathological conditions. Initially identified in the context of the immune system, GPR83 is expressed in various tissues, including the central nervous system, and has been linked to hormonal regulation, stress responses, and metabolic control. Its involvement in immune cell function suggests a role in inflammatory diseases and autoimmune conditions. Recent studies have indicated that GPR83 may play a crucial role in modulating the function of immune cells, particularly T cells and macrophages. Given its significance, researchers have focused on producing recombinant GPR83 protein to elucidate its structure and function further. Recombinant protein studies enable the characterization of GPR83's ligand-binding properties, signaling pathways, and interactions with other cellular components. Understanding the molecular mechanisms of GPR83 could open new avenues for therapeutic interventions, especially in metabolic disorders and immune-related diseases. Thus, the exploration of GPR83 as a potential drug target and the creation of a recombinant protein model pave the way for a deeper understanding of its biological roles and therapeutic prospects.
