Cat: PA1000-1122

Recombinant Human FGFR1OP Protein,His

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Analytical Data

  • Gene name

    FGFR1OP

  • Application

    SPRMSTBLIITCELISACELL ASSAYDRUG SCREENING

  • Alternative Names

    FGFR1OP;FGFR1OP;FOP;Centrosomal Protein 43

  • Species

    Human

  • Source

    E. coli

  • Tag

    His tag N-Terminus

  • Purity

    Greater than 90% as determined by SDS-PAGE.

  • Uniprot

    O95684

  • Expression Region

    1-399aa

  • AA Sequence

    MAATAAAVVA EEDTELRDLL VQTLENSGVL NRIKAELRAA VFLALEEQEK VENKTPLVNE SLKKFLNTKD GRLVASLVAE FLQFFNLDFT LAVFQPETST LQGLEGRENL ARDLGIIEAE GTVGGPLLLE VIRRCQQKEK GPTTGEGALD LSDVHSPPKS PEGKTSAQTT PSKIPRYKGQ GKKKTSGQKA GDKKANDEAN QSDTSVSLSE PKSKSSLHLL SHETKIGSFL SNRTLDGKDK AGLCPDEDDM EGDSFFDDPI PKPEKTYGLR KEPRKQAGSL ASLSDAPPLK SGLSSLAGAP SLKDSESKRG NTVLKDLKLI SDKIGSLGLG TGEDDDYVDD FNSTSHRSEK SEISIGEEIE EDLSVEIDDI NTSDKLDDLT QDLTVSQLSD VADYLEDVA

  • Endotoxin

    < 1.0 EU per μg protein as determined by the LAL method.

  • Form

    Freeze-dried powder

  • Buffer formulation

    PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.

  • Reconstitution

    Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.

  • Customization

    Site-directed mutagenesis Custom tag design Custom buffer formulation Custom full-length protein production

  • Stability Test

    The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.

  • Storage & Shelf Life

    Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.

  • Shipping

    In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.

Quality inspection process

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Protein Description

FGFR1OP (FGFR1 Oncogene Partner) is a protein that has garnered significant attention in the fields of cancer research and molecular biology due to its involvement in various cellular processes and oncogenic pathways. It was initially identified as a fusion partner for the FGFR1 gene in certain hematological malignancies, suggesting its role in tumorigenesis. FGFR1OP plays a crucial role in the regulation of cellular growth, differentiation, and survival, making it a potential target for therapeutic intervention. Research has shown that aberrant expression or mutation of FGFR1OP can lead to dysregulation of signaling pathways associated with cancer progression. Understanding the molecular mechanisms underlying FGFR1OP’s function and its interactions with other oncogenic proteins is essential for elucidating its role in neoplastic transformation. Furthermore, examining FGFR1OP’s involvement in signal transduction pathways may provide insights into new treatment options for cancers exhibiting FGFR1 alterations. Given the complexity of its interactions and the clinical implications of FGFR1OP dysregulation, ongoing studies are aimed at developing FGFR1OP-targeted therapies, with the hope of improving patient outcomes in specific cancer types.

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