Analytical Data
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基因名
HSD17B10
- Application
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别名
TRMT10C;MRPP1;RG9MTD1;tRNA methyltransferase 10 homolog C
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
Q99714
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表达区间
2-261aa
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氨基酸序列
AAACRSVKGLVAVITGGASGLGLATAERLVGQGASAVLLDLPNSGGEAQAKKLGNNCVFAPADVTSEKDVQTALALAKGKFGRVDVAVNCAGIAVASKTYNLKKGQTHTLEDFQRVLDVNLMGTFNVIRLVAGEMGQNEPDQGGQRGVIINTASVAAFEGQVGQAAYSASKGGIVGMTLPIARDLAPIGIRVMTIAPGLFGTPLLTSLPEKVCNFLASQVPFPSRLGDPAEYAHLVQAIIENPFLNGEVIRLDGAIRMQP
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分子量
42.8kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
HSD17B10, or hydroxysteroid 17-beta dehydrogenase 10, is a mitochondrial enzyme involved in the metabolism of steroids and plays a crucial role in the regulation of various biological processes, including steroid hormone biosynthesis and the catabolism of neuroactive steroids. Recent studies have highlighted its significant involvement in neurodegenerative diseases, particularly Alzheimer’s disease, where it has been linked to alterations in steroid metabolism and neuroinflammation. The enzyme exists in multiple forms, and its expression is tissue-specific, indicating its potential role in diverse physiological and pathological conditions. Given its importance, the recombinant expression of HSD17B10 is critical for further research, allowing scientists to explore its enzymatic properties, regulatory mechanisms, and biochemical pathways. The production of the recombinant protein facilitates detailed structural analyses and functional assays that are essential for understanding its role in health and disease. Moreover, studying HSD17B10 can offer insights into developing therapeutic strategies for conditions associated with steroid imbalance and neurodegenerative disorders. As such, the research on recombinant HSD17B10 not only enhances our comprehension of this enzyme's biological functions but also opens avenues for potential clinical applications in treating related ailments.
