Analytical Data
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基因名
GJb1
- Application
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别名
GJb1；CX32；Gap junction beta-1 Protein
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P08034
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表达区间
1-283aa
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氨基酸序列
MNWTGLYTLLSGVNRHSTAIGRVWLSVIFIFRIMVLVVAAESVWGDEKSSFICNTLQPGCNSVCYDQFFPISHVRLWSLQLILVSTPALLVAMHVAHQQHIEKKMLRLEGHGDPLHLEEVKRHKVHISGTLWWTYVISVVFRLLFEAVFMYVFYLLYPGYAMVRLVKCDVYPCPNTVDCFVSRPTEKTVFTVFMLAASGICIILNVAEVVYLIIRACARRAQRRSNPPSRKGSGFGHRLSPEYKQNEINKLLSEQDGSLKDILRRSPGTGAGLAEKSDRCSAC
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分子量
32 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
GJB1, also known as Gap Junction Protein Beta 1, is a crucial component of gap junctions, which facilitate direct intercellular communication through the exchange of ions and small molecules. Mutations in the GJB1 gene are associated with various neurological disorders, particularly Charcot-Marie-Tooth disease type 1X (CMT1X), a hereditary neuropathy that significantly affects motor and sensory functions. The study of GJB1 recombinant proteins has gained prominence due to its potential for elucidating the mechanisms underlying these mutations and their phenotypic manifestations. Additionally, researching GJB1 can provide insights into the physiological roles of gap junctions in cellular communication, which is vital for maintaining tissue homeostasis and function. The recombinant expression of GJB1 allows for the production of functional proteins that can be used in both in vitro and in vivo models, facilitating the exploration of their physiological and pathological roles. Understanding the structure-function relationship of GJB1 is fundamental to developing therapeutic strategies for conditions arising from its dysfunction. Thus, research on GJB1 recombinant proteins is critical not only for advancing genetic and molecular understanding of related diseases but also for exploring innovative therapeutic approaches to mitigate their effects.
