Analytical Data
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基因名
KLHL18
- Application
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别名
FLJ13703; Kelch like 18 (Drosophila) ; Kelch like 18; Kelch-like protein 18; KIAA0795; KLH18_HUMAN; KLHL 18; KLHL18
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种属
Human
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表达系统
E. coli
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标签
GST-tag at N-terminal
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
O94889
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表达区间
1-574aa
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氨基酸序列
MVEDGAEELE DLVHFSVSEL PSRGYGVMEE IRRQGKLCDV TLKIGDHKFS AHRIVLAASI PYFHAMFTND MMECKQDEIV MQGMDPSALE ALINFAYNGN LAIDQQNVQS LLMGASFLQL QSIKDACCTF LRERLHPKNC LGVRQFAETM MCAVLYDAAN SFIHQHFVEV SMSEEFLALP LEDVLELVSR DELNVKSEEQ VFEAALAWVR YDREQRGPYL PELLSNIRLP LCRPQFLSDR VQQDDLVRCC HKCRDLVDEA KDYHLMPERR PHLPAFRTRP RCCTSIAGLI YAVGGLNSAG DSLNVVEVFD PIANCWERCR PMTTARSRVG VAVVNGLLYA IGGYDGQLRL STVEAYNPET DTWTRVGSMN SKRSAMGTVV LDGQIYVCGG YDGNSSLSSV ETYSPETDKW TVVTSMSSNR SAAGVTVFEG RIYVSGGHDG LQIFSSVEHY NHHTATWHPA AGMLNKRCRH GAASLGSKMF VCGGYDGSGF LSIAEMYSSV ADQWCLIVPM HTRRSRVSLV ASCGRLYAVG GYDGQSNLSS VEMYDPETDC WTFMAPMACH EGGVGVGCIP LLTI
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分子量
89.54 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KLHL18, a member of the Kelch-like protein family, is an important protein involved in various cellular processes, including the regulation of the cytoskeleton, protein degradation, and the maintenance of cellular homeostasis. Its structure features multiple Kelch motifs, which commonly mediate protein-protein interactions, thus positioning KLHL18 as a potential player in signaling pathways and cellular responses to stress. Recent studies have suggested that KLHL18 may be implicated in developmental processes and certain diseases, including cancer and neurodegenerative disorders. Research on KLHL18 recombinant protein has gained momentum as scientists aim to elucidate its precise biological functions and mechanisms. By expressing KLHL18 in a recombinant system, researchers can produce sufficient quantities of the protein for detailed biochemical and biophysical analyses. This could provide insights into how KLHL18 interacts with other proteins and its role in cellular signaling networks. Understanding KLHL18's function and interactions could pave the way for novel therapeutic strategies targeting its signaling pathways in disease contexts. Overall, KLHL18’s role in crucial biological processes underscores the importance of studying its recombinant form to enhance our understanding of its contribution to health and disease.
