Analytical Data
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基因名
Maspin
- Application
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别名
SERPINB5;PI5;Serpin B5
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种属
Human
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表达系统
E. coli
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标签
His tag N-Terminus
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纯度
Greater than 90% as determined by SDS-PAGE.
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蛋白编号
P36952
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表达区间
1-375aa
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氨基酸序列
MDALQLANSA FAVDLFKQLC EKEPLGNVLF SPICLSTSLS LAQVGAKGDT ANEIGQVLHF ENVKDVPFGF QTVTSDVNKL SSFYSLKLIK RLYVDKSLNL STEFISSTKR PYAKELETVD FKDKLEETKG QINNSIKDLT DGHFENILAD NSVNDQTKIL VVNAAYFVGK WMKKFSESET KECPFRVNKT DTKPVQMMNM EATFCMGNID SINCKIIELP FQNKHLSMFI LLPKDVEDES TGLEKIEKQL NSESLSQWTN PSTMANAKVK LSIPKFKVEK MIDPKACLEN LGLKHIFSED TSDFSGMSET KGVALSNVIH KVCLEITEDG GDSIEVPGAR ILQHKDELNA DHPFIYIIRH NKTRNIIFFG KFCSP
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分子量
46 kDa
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内毒素
< 1.0 EU per μg protein as determined by the LAL method.
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性状
Freeze-dried powder
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缓冲液
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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复溶方法
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- 个性化定制
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稳定性测试
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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保存条件 & 期限
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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运输条件
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
Maspin (Mammary Serine Protease Inhibitor) is a member of the serpin superfamily and is primarily known for its role as a tumor suppressor in breast cancer. Its expression is often downregulated in various malignant tumors, correlating with poorer prognosis and aggressive disease. Maspin is thought to exert its effects by inhibiting serine proteases, modulating cell motility, and influencing apoptosis, thereby impacting tumor growth and progression. Research has shown that maspin can disrupt the interaction between cancer cells and the extracellular matrix, reducing invasion and metastasis, which underscores its potential therapeutic significance. Additionally, maspin has been implicated in regulating immune responses within the tumor microenvironment. Given these multifaceted roles, the study of recombinant maspin protein has gained traction, focusing on its structural properties, functional mechanisms, and potential applications in cancer therapy. Efforts to develop recombinant maspin proteins are aimed at exploring their utility as therapeutic agents or biomarkers in oncology. Understanding the biology and applications of maspin could lead to innovative strategies for the prevention and treatment of breast cancer and possibly other malignancies, highlighting the need for continued research into its reconstitution and clinical relevance.
