Analytical Data
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Gene name
KRTAP19-1
- Application
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Alternative Names
KRTAP19-1; KAP19.1; KRTAP19.1; Keratin-associated protein 19-1; High tyrosine-glycine keratin-associated protein 19.1
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Species
Human
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Source
E. coli
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Tag
GST-tag at N-terminal
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Purity
Greater than 90% as determined by SDS-PAGE.
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Uniprot
Q8IUB9
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Expression Region
1-90aa
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AA Sequence
MSHYGSYYGGLGYSCGGFGGLGYGYGCGCGSFCRRGSGCGYGGYGYGSGFGSYGYGSGFGGYGYGSGFGGYGYGCCRPSYNGGYGFSGFY
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Molecular Weight
9.9 kDa
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Endotoxin
< 1.0 EU per μg protein as determined by the LAL method.
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Form
Freeze-dried powder
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Buffer formulation
PBS, pH7.4, containing 0.01% SKL, 1mM DTT, 5% Trehalose and Proclin300.
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Reconstitution
Reconstitute in ddH2O to a concentration of 0.1-0.5 mg/mL. Do not vortex.
- Customization
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Stability Test
The thermal stability is described by the loss rate. The loss rate was determined by accelerated thermal degradation test, that is, incubate the protein at 37℃ for 48h, and no obvious degradation and precipitation were observed. The loss rate isless than 8% within the expiration date under appropriate storage condition.
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Storage & Shelf Life
Samples are stable for up to twelve months from date of receipt at -20℃ to -80℃. Store it under sterile conditions at -20℃ to -80℃. It is recommended that the protein be aliquoted for optimal storage. Avoid repeated freeze-thaw cycles.
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Shipping
In general, recombinant proteins are supplied as lyophilized powder and shipped at ambient temperature. For bulk packages, the proteins are provided as frozen liquid and shipped with blue ice, unless otherwise requested by the customer.
Quality inspection process
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Protein Description
KRTAP19-1, a member of the keratin-associated protein (KAP) family, has garnered significant interest in the field of molecular biology and dermatological research due to its role in skin and hair follicle biology. These proteins are primarily expressed in the outer root sheath of hair follicles and are believed to contribute to the structural integrity and mechanical properties of hair. Understanding the functionality and interactions of KRTAP19-1 is crucial, as mutations or dysregulation in KAPs can lead to a variety of hair disorders and skin conditions. Recent studies have highlighted its potential involvement in the differentiation of keratinocytes and its contribution to the formation of the hair shaft, underscoring its importance in maintaining healthy hair growth cycles. Furthermore, the recombinant production of KRTAP19-1 allows for detailed examination of its biochemical properties and potential applications in therapeutic strategies for hair loss and skin repair. By studying the structure-function relations of KRTAP19-1, researchers aim to uncover its roles in cellular signaling pathways, protein interactions, and tissue architecture, paving the way for advancements in dermatological treatments and regenerative medicine.
